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Impairment of tissue repair in pneumonia due to β-cell deficiency: role of endoplasmic reticulum stress in alveolar macrophages
http://hdl.handle.net/10069/38960
http://hdl.handle.net/10069/3896047982e36-7c55-4b80-9ca3-41e8d17bef62
| 名前 / ファイル | ライセンス | アクション |
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BMCRN12_160.pdf (998.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
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| 公開日 | 2019-04-17 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | Impairment of tissue repair in pneumonia due to β-cell deficiency: role of endoplasmic reticulum stress in alveolar macrophages | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Diabetes mellitus | |||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Endoplasmic reticulum stress | |||||||||||||||||||
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| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Hepatocyte growth factor | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Pneumonia | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| 著者 |
Yamashita, Yoshiro
× Yamashita, Yoshiro
× Kuroki, Reiki
× Takaki, Masahiro
× Tanaka, Takeshi
× Senba, Masachika
× Morimoto, Konosuke
× Amano, Hideaki
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| 抄録 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | Objective: Diabetes mellitus (DM) patients are susceptible to delayed resolution of pneumonia.However, the pathogenesis of the impaired tissue repair in inflamed lungs in diabetic patients is unknown. We evaluated phagocytosis of apoptotic cells(efferocytosis), hepatocyte growth factor (HGF) production in bronchoalveolar lavage fluid (BALF), and lung histology in the resolution phase following acute lung injury in streptozotocin (STZ)-induced β-cell-depleted hyperglycemic mice. We also investigated efferocytosis and HGF production by macrophages under β-cell depletion condition ex vivo. Results: In β-cell-depleted mice, efferocytosis was not significantly different from that in control mice; however, the concentration of HGF in BALF was decreased. In addition, diminished HGF production by alveolar macrophages and DNA synthesis in the alveolar epithelium was observed by immunohistochemistry. Ex vivo experiments confirmed that HGF production by macrophages was impaired under β-cell depletion probably because of endoplasmic reticulum stress. |
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| 書誌情報 |
BMC Research Notes 巻 12, 号 1, p. 160, 発行日 2019-03-22 |
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| 出版者 | ||||||||||||||||||||
| 出版者 | BioMed Central Ltd. | |||||||||||||||||||
| EISSN | ||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||
| 収録物識別子 | 17560500 | |||||||||||||||||||
| DOI | ||||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | 10.1186/s13104-019-4209-0 | |||||||||||||||||||
| 権利 | ||||||||||||||||||||
| 権利情報 | c The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium,provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license,and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
| 引用 | ||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||
| 内容記述 | BMC Research Notes, 12(1), art.no.160; 2019 | |||||||||||||||||||
