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アイテム
Diagnostic Utility of Cytomegalovirus Nucleic Acid Testing during Antigenemia-Guided Cytomegalovirus Monitoring after Hematopoietic Stem Cell Transplantation or Liver Transplantation
http://hdl.handle.net/10069/38964
http://hdl.handle.net/10069/3896482dae5c7-9797-4163-92f7-e115cda72ed2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
TJEM247_179.pdf (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2019-04-17 | |||||
| タイトル | ||||||
| タイトル | Diagnostic Utility of Cytomegalovirus Nucleic Acid Testing during Antigenemia-Guided Cytomegalovirus Monitoring after Hematopoietic Stem Cell Transplantation or Liver Transplantation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | automation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | immunocompromised | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | monitoring | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | nucleic acid test | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | pre-engraftment phase | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Morinaga, Yoshitomo
× Morinaga, Yoshitomo× Sawayama, Yasushi× Hidaka, Masaaki× Mori, Sayaka× Taguchi, Jun× Takatsuki, Mitsuhisa× Eguchi, Susumu× Miyazaki, Yasushi× Yanagihara, Katsunori |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Cytomegalovirus (CMV) is an opportunistic pathogen, and careful monitoring of CMV is important for immunocompromised patients. Antigenemia-based CMV monitoring is a standard test used for managing CMV infection in transplant recipients;however, in Japan, there are no reports of CMV monitoring using the standardized test. The utility of a standardized CMV nucleic acid test (NAT) was evaluated during antigenemia-based CMV monitoring after hematopoietic stem cell transplantation (HSCT) or liver transplantation. Blood collection for CMV monitoring was performed under the physician's instructions depending on the condition of the patient, and CMV NAT and antigenemia was evaluated. For HSCT recipients, blood collection only for NAT was additionally performed during the pre-engraftment phase. The results of the NAT were blinded to those evaluating the results. A total of 34 patients were enrolled (11 HSCT recipients and 23 liver transplant recipients). NAT detected the first CMV episode no later than antigenemia in 2 (18.2%) HSCT recipients and 3 (13.0%) liver transplant recipients, earlier than antigenemia in 3 (27.3%) HSCT recipients and 7 (30.4%) liver transplant recipients, and later than antigenemia in 1 (9.1%) HSCT recipient and 1 (4.3%) liver transplant recipient. In 5 HSCT recipients, NAT was positive during the pre-engraftment phase. Among the 468 blood samples which were evaluated by both NAT and antigenemia, 124 (26.7%) were positive in NAT and 51 (10.9%) were positive in antigenemia. The standardized CMV NAT is useful for accurately diagnosing CMV infection and determining appropriate therapeutic interventions for HSCT recipients and liver transplant recipients. | |||||
| 書誌情報 |
The Tohoku Journal of Experimental Medicine 巻 247, 号 3, p. 179-187, 発行日 2019-03-19 |
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| 出版者 | ||||||
| 出版者 | 東北ジャーナル刊行会 | |||||
| 出版者別言語 | ||||||
| 値 | Tohoku University Medical Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00408727 | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13493329 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1620/tjem.247.179 | |||||
| 権利 | ||||||
| 権利情報 | c 2019 Tohoku University Medical Press | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The Tohoku journal of experimental medicine, 247(3), pp.179-187; 2019 | |||||
