WEKO3
アイテム
Akt regulates skeletal development through GSK3, mTOR, and FoxOs
http://hdl.handle.net/10069/21352
http://hdl.handle.net/10069/2135278bf4a00-81f4-4a83-80b5-9da5bd59dd9d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DevBio328_78.pdf (3.9 MB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-03-17 | |||||
| タイトル | ||||||
| タイトル | Akt regulates skeletal development through GSK3, mTOR, and FoxOs | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Akt | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cartilage matrix | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cell growth | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Chondrocyte maturation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Chondrocyte proliferation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | FoxO | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | GSK3 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mTOR | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Skeletal development | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Transgenic mouse | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Rokutanda, Satoshi
× Rokutanda, Satoshi× Fujita, Takashi× Kanatani, Naoko× Yoshida, Carolina A.× Komori, Hisato× Liu, Wenguang× Mizuno, Akio× Komori, Toshihisa |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Although Akt plays key roles in various cellular processes, the functions of Akt and Akt downstream signaling pathways in the cellular processes of skeletal development remain to be clarified. By analyzing transgenic embryos that expressed constitutively active Akt (myrAkt) or dominant-negative Akt in chondrocytes, we found that Akt positively regulated the four processes of chondrocyte maturation, chondrocyte proliferation, cartilage matrix production, and cell growth in skeletal development. As phosphorylation of GSK3β, S6K, and FoxO3a was enhanced in the growth plates of myrAkt transgenic mice, we examined the Akt downstream signaling pathways by organ culture. The Akt-mTOR pathway was responsible for positive regulation of the four cellular processes. The Akt-FoxO pathway enhanced chondrocyte proliferation but inhibited chondrocyte maturation and cartilage matrix production, while the Akt-GSK3 pathway negatively regulated three of the cellular processes in limb skeletons but not in vertebrae due to less GSK3 expression in vertebrae. These findings indicate that Akt positively regulates the cellular processes of skeletal growth and endochondral ossification, that the Akt-mTOR, Akt-FoxO, and Akt-GSK3 pathways positively or negatively regulate the cellular processes, and that Akt exerts its function in skeletal development by tuning the three pathways in a manner dependent on the skeletal part. | |||||
| 書誌情報 |
Developmental Biology 巻 328, 号 1, p. 78-93, 発行日 2009-04-01 |
|||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00121606 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00627848 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.ydbio.2009.01.009 | |||||
| 権利 | ||||||
| 権利情報 | Copyright (c) 2009 Elsevier Inc. All rights reserved. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Developmental Biology, 328(1), pp.78-93; 2009 | |||||
