| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2009-05-13 |
| タイトル |
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タイトル |
Loss of Tumor Necrosis Factor Production by Human Monocytes in Falciparum Malaria after Their Maturation in Vitro |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Nagao, Takayoshi
Uemura, Haruki
Yanagi, Tetsuo
Oishi, Kazunori
Nagatake, Tsuyoshi
Kanbara, Hiroji
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
In Plasmodium-infected mammals, phagocytosis and production of tumor necrosis factor (TNF) by monocytes and macrophages are prominent features. The present work aimed at clarifying the relationship between the maturation of human monocytes to macrophages and their TNF productivity and phagocytic ability in the presence of Plasmodium falciparum-infected erythrocytes. Fresh monocytes produced a significantly higher quantity of TNF in the presence of schizont-infected erythrocytes than macrophages obtained by in vitro monocyte maturation on autologous serum, whereas phagocytic activity of macrophages was much higher than that of fresh monocytes. This indicated that the TNF-inducing factors from P. falciparum-infected erythrocytes could stimulate fresh monocytes, but not macrophages, to release TNF, regardless of their development of phagocytosis. Activation of macrophages by interferon-{gamma} could not recover their TNF productivity in the presence of P. falciparum-infected erythrocytes, but it enhanced their TNF productivity in the presence of lipopolysaccharide(s). The TNF-inducing factors were contained mainly in erythrocytes infected with mature schizonts but not in erythrocytes infected with the younger stages of the parasites. Fractionation of infected erythrocytes revealed that both soluble and insoluble components almost equally contained those factors. |
| 書誌情報 |
American Journal of Tropical Medicine and Hygiene
巻 55,
号 5,
p. 562-566,
発行日 1996-11
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| 出版者 |
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出版者 |
American Society of Tropical Medicine and Hygiene |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00029637 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00521439 |
| PubMed番号 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
PMID |
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関連識別子 |
8940991 |
| 権利 |
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|
権利情報 |
Copyright c 1996 by The American Society of Tropical Medicine and Hygiene |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関係URI |
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|
関連名称 |
http://www.ajtmh.org/cgi/content/abstract/55/5/562 |
| 引用 |
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内容記述タイプ |
Other |
|
内容記述 |
American Journal of Tropical Medicine and Hygiene, 55(5), pp.562-566; 1996 |
ajtmh55_562.pdf (584.7 kB)
