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In Vivo Anti-estrogenic Effects of Menadione on Hepatic Estrogen-responsive Gene Expression in Male Medaka (Oryzias latipes)
http://hdl.handle.net/10069/20173
http://hdl.handle.net/10069/201733b12d632-bf4d-4e0c-86e7-61d1c7cd67ce
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
JHS54_596.pdf (276.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-11-14 | |||||
| タイトル | ||||||
| タイトル | In Vivo Anti-estrogenic Effects of Menadione on Hepatic Estrogen-responsive Gene Expression in Male Medaka (Oryzias latipes) | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | menadione | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | anti-estrogenic | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | oryzias latipes, in vivo | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Yamaguchi, Akemi
× Yamaguchi, Akemi× Kohra, Shinya× Ishibashi, Hiroshi× Arizono, Koji× Tominaga, Nobuaki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Menadione, a synthetic vitamin K3, exhibits anti-estrogenic activity on in vitro assay. However, the in vivo anti-estrogenic effects of menadione have not been determined, while correlations between biological effects and structural changes are unclear. Thus, we investigated the in vivo anti-estrogenic activity of menadione under fluorescent light and dark conditions. Suppression of the hepatic estrogen response genes vitellogenin1 (VTG1), VTG2 and estrogen receptor-α (ER-α) was used as an index of antiestrogenic activity. Male medaka (Oryzias latipes) were treated with nominal concentrations of menadione in the presence or absence of 17β-estradiol (E2), and hepatic VTG1, VTG2 and ER-α mRNA levels were determined by quantitative real-time PCR. In the presence of E2 under dark conditions, expression of hepatic VTG2 and ER-α genes was suppressed by menadione treatment. On the other hand, menadione activity was lost under fluorescent light conditions. These results suggest that menadione has antiestrogenic activity in vivo, and that this activity is diminished under fluorescent light, probably due to a structural change in menadione. | |||||
| 書誌情報 |
JOURNAL OF HEALTH SCIENCE 巻 54, 号 5, p. 596-601, 発行日 2008-10 |
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| 出版者 | ||||||
| 出版者 | The Pharmaceutical Society of Japan | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13449702 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11316464 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1248/jhs.54.596 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal of Health Science, 54(5), pp.596-601; 2008 | |||||
