| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2008-07-17 |
| タイトル |
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|
タイトル |
Long-term effects of polychlorinated biphenyls and dioxins on pregnancy outcomes in women affected by the Yusho incident |
| 言語 |
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言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Dioxin |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Environmental exposure |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
Pregnancy loss |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
Preterm delivery |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
Spontaneous abortion |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
Yusho |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Tsukimori, Kiyomi
Tokunaga, Shoji
Shibata, Satoko
Uchi, Hiroshi
Nakayama, Daisuke
Ishimaru, Tadayuki
Nakano, Hitoo
Wake, Norio
Yoshimura, Takesumi
Furue, Masutaka
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Background: Maternal exposure to polychlorinated biphenyls (PCBs) is associated with increased proportions of spontaneous abortion and stillbirth in animal studies. In Japan in 1968, accidental human exposure to rice oil contaminated with PCBs and other dioxin-related compounds, such as polychlorinated dibenzofurans (PCDFs), led to the development of what was later referred to as Yusho oil disease. Objective: The aim of this study was to investigated the association of maternal PCB and dioxin exposure with adverse pregnancy outcomes in Yusho women. Methods: In 2004, we interviewed 214 Yusho women (512 pregnancies) about their pregnancy outcomes over the past 36 years. Pregnancy outcomes included induced abortion, spontaneous abortion, preterm delivery, and pregnancy loss. Results: In pregnancy years 1968-1977 (within the first 10 years after exposure), the proportions of induced abortion [adds ration adjusted for age at delivery (ORadj) = 5.93; 95% confidence interval (CI), 2.21-15.91; two-tailed p < 0.001) and preterm delivery (ORadj = 5.70; 95% CI, 1.17-27.79; p = 0.03) were significantly increased compared with the proportions in pregnancy years 1958-1967 (10 years before the incident). Spontaneous abortion (ORadj = 2.09; 95% CI, 0.84-5.18), and pregnancy loss (ORadj = 2.11; 95% CI, 0.92-4.87) were more frequent (OR = 2.18; 95% CI, 1.02-4.66), but these were not significant (p = 0.11 and p = 0.08, respectively) in pregnancy years 1968-1977. We found no significant increases in the proportions of these adverse pregnancy outcomes in pregnancies occurring during 1978-1987 or 1988-2003 compared with those in pregnancies before 1968. Conclusion: High levels of PCB/PCDF exposure had some adverse effects on pregnancy outcome in Yusho women. |
| 書誌情報 |
Environmental Health Perspectives
巻 116,
号 5,
p. 626-630,
発行日 2008-05
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| 出版者 |
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出版者 |
US Department of Health and Human Services |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00916765 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00180451 |
| PubMed番号 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
PMID |
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関連識別子 |
18470296 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1289/ehp.10686 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
|
内容記述 |
Environmental Health Perspectives, 116(5), pp.626-630; 2008 |
EHP116_626.pdf (141.0 kB)
