| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2008-08-12 |
| タイトル |
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タイトル |
Telomerase Activity, Telomere Length, and Chromosome Aberrations in the Extension of Life Span of Human Embryo Cells Induced by Low-dose X-rays |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
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主題Scheme |
Other |
|
主題 |
X-rays |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
Low dose |
| キーワード |
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主題Scheme |
Other |
|
主題 |
Lifespan |
| キーワード |
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主題Scheme |
Other |
|
主題 |
Telomerase activity |
| キーワード |
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主題Scheme |
Other |
|
主題 |
Telomere |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Yang, Zhi
Kodama, Seiji
Suzuki, Keiji
Watanabe, Masami
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
We examined whether the shortening of telomere structure is related to in vitro cellular aging after multiple low-dose irradiation. We used three strains of HE cells (HE23, HE31, and HE40) exhibiting different levels of telomerase activity and irradiated these cells twice a week with a dose of 2 cGy or 4 cGy of X-rays until they senesced. The cells were in total exposed to doses of 52-208 cGy of X-rays. Only the HE31 cells, which had no telomerase activity, experienced an increase in the number of cell divisions, reaching a maximum of 120-124% of the non-irradiated controls. However, in two strains which did exhibit telomerase activity in an early passage in culture, no extension of cell life span was found. Telomerase-positive cells completely lost all telomerase activity when the cells were subcultured several times without irradiation. In the HE31 cells where the life span was extended, the ratio of cell having a long telomere was higher than those of the other two cells (HE23 and HE40). Cytogenetic analysis revealed that the life span extension due to multiple low-dose irradiation which was observed in HE31 cells did not correlate with specific chromosome alterations. Our results suggest that the telomerase activity remaining in the cells at an early passage does not correlate with the extension of life span in vitro by X-irradiation. The factor other than telomerase activity may play an important role in the regulation of telomere length and the extension of life span. |
| 書誌情報 |
Journal of radiation research
巻 39,
号 1,
p. 35-51,
発行日 1998-03
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| 出版者 |
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出版者 |
日本放射線影響学会 |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
04493060 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00705792 |
| 権利 |
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権利情報 |
日本放射線影響学会 |
| 権利 |
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|
権利情報 |
本文データは学協会の許諾に基づきCiNiiから複製したものである |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Journal of radiation research. 1998, 39(1), p.35-51 |
RR39_1_35_51.pdf (888.9 kB)
