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Ocular Pharmacokinetic/Pharmacodynamic Modeling for Timolol in Rabbits Using a Telemetry System
http://hdl.handle.net/10069/17913
http://hdl.handle.net/10069/17913d793e02e-d2f0-4560-b4f7-4104e0e0628b
名前 / ファイル | ライセンス | アクション |
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BPB31_970.pdf (199.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-06-30 | |||||
タイトル | ||||||
タイトル | Ocular Pharmacokinetic/Pharmacodynamic Modeling for Timolol in Rabbits Using a Telemetry System | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pharmacokinetic | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pharmacodynamic | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | eye | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | timolol | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | telemetry system | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Sakanaka, Koji
× Sakanaka, Koji× Kawazu, Kouichi× Tomonari, Masahide× Kitahara, Takashi× Nakashima, Mikiro× Nishida, Koyo× Nakamura, Junzo× Sasaki, Hitoshi× Higuchi, Shun |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We have established an ocular pharmacokinetic/pharmacodynamic (PK/PD) model for a β-adrenergic antagonist, timolol, after instillation into rabbits. Timolol concentrations were determined by HPLC in the tear fluid, aqueous humor, cornea, and iris-ciliary body after instillation or ocular injection into the anterior chamber of the eye in rabbits. In addition, intraocular pressure (IOP) measurement was performed after instillation of timolol by a telemetry system, which was able to obtain detailed IOP data automatically. The PK/PD parameters were estimated by fitting the concentration--time profiles and the ocular hypotensive effect--time profiles using MULTI (RUNGE) program. The PK model consisted of six compartments and the PD model included aqueous humor dynamics based on an action mechanism of timolol, which causes lowering of IOP by suppressing aqueous humor production. The PK/PD model described well the concentration--time profiles and the ocular hypotensive effect--time profiles after instillation of timolol. This study is the first trial to develop an ocular PK/PD model for timolol after instillation. This model can predict both the drug concentrations in various ocular tissues and the ocular hypotensive effect after instillation of timolol. | |||||
書誌情報 |
Biological & Pharmaceutical Bulletin 巻 31, 号 5, p. 970-975, 発行日 2008-05-01 |
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出版者 | ||||||
出版者 | The Pharmaceutical Society of Japan | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09186158 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13475215 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10885497 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.31.970 | |||||
権利 | ||||||
権利情報 | (c) 2008 The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biological & Pharmaceutical Bulletin, 31(5), pp.970-975; 2008 |