{"_buckets": {"deposit": "6a3f4d2f-e0f1-4c06-adb9-704705a57009"}, "_deposit": {"created_by": 6, "id": "2000075", "owner": "6", "owners": [6], "pid": {"revision_id": 0, "type": "depid", "value": "2000075"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:02000075", "sets": ["11"]}, "author_link": [], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2023-06-23", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageStart": "art. no. 666", "bibliographicVolumeNumber": "6", "bibliographic_titles": [{"bibliographic_title": "Communications Biology", "bibliographic_titleLang": "en"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Activation of the cholinergic anti-inflammatory pathway (CAP) via vagus nerve stimulation has been shown to improve acute kidney injury in rodent models. While alpha 7 nicotinic acetylcholine receptor (α7nAChR) positive macrophages are thought to play a crucial role in this pathway, their in vivo significance has not been fully understood. In this study, we used macrophage-specific α7nAChR-deficient mice to confirm the direct activation of α7nAChRs in macrophages. Our findings indicate that the administration of GTS-21, an α7nAChR-specific agonist, protects injured kidneys in wild-type mice but not in macrophage-specific α7nAChR-deficient mice. To investigate the signal changes or cell reconstructions induced by α7nAChR activation in splenocytes, we conducted single-cell RNA-sequencing of the spleen. Ligand-receptor analysis revealed an increase in macrophage-macrophage interactions. Using macrophage-derived cell lines, we demonstrated that GTS-21 increases cell contact, and that the contact between macrophages receiving α7nAChR signals leads to a reduction in TNF-α. Our results suggest that α7nAChR signaling increases macrophage-macrophage interactions in the spleen and has a protective effect on the kidneys.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Communications Biology, 6(1), art. no. 666; 2023", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer Nature", "subitem_publisher_language": "en"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1038/s42003-023-05051-2", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0. © The Author(s) 2023.", "subitem_rights_language": "en"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2399-3642", "subitem_source_identifier_type": "EISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nakamura, Yasuna", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Matsumoto, Hirotaka", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Wu, Chia-Hsien", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Fukaya, Daichi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Uni, Rie", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Hirakawa, Yosuke", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Katagiri, Mikako", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yamada, Shintaro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ko, Toshiyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Nomura, Seitaro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Wada, Youichiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Komuro, Issei", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Nangaku, Masaomi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Inagi, Reiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Inoue, Tsuyoshi", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2023-07-25"}], "download_preview_message": "", "file_order": 0, "filename": "CB6_666.pdf", "filesize": [{"value": "3.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "application/pdf", "size": 3700000.0, "url": {"url": "https://nagasaki-u.repo.nii.ac.jp/record/2000075/files/CB6_666.pdf"}, "version_id": "a7f0d2b9-71af-4a95-a9c4-9b9854c79d48"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Alpha 7 nicotinic acetylcholine receptors signaling boosts cell-cell interactions in macrophages effecting anti-inflammatory and organ protection", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Alpha 7 nicotinic acetylcholine receptors signaling boosts cell-cell interactions in macrophages effecting anti-inflammatory and organ protection", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "6", "path": ["11"], "permalink_uri": "http://hdl.handle.net/10069/0002000075", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2023-07-25"}, "publish_date": "2023-07-25", "publish_status": "0", "recid": "2000075", "relation": {}, "relation_version_is_last": true, "title": ["Alpha 7 nicotinic acetylcholine receptors signaling boosts cell-cell interactions in macrophages effecting anti-inflammatory and organ protection"], "weko_shared_id": -1}
Alpha 7 nicotinic acetylcholine receptors signaling boosts cell-cell interactions in macrophages effecting anti-inflammatory and organ protection
http://hdl.handle.net/10069/0002000075
http://hdl.handle.net/10069/0002000075