{"_buckets": {"deposit": "9f000f31-884f-44b9-a448-e67eaf2359e8"}, "_deposit": {"created_by": 6, "id": "2000489", "owner": "6", "owners": [6], "pid": {"revision_id": 0, "type": "depid", "value": "2000489"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:02000489", "sets": ["36"]}, "author_link": [], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2023-12-15", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "68", "bibliographicPageStart": "59", "bibliographicVolumeNumber": "139", "bibliographic_titles": [{"bibliographic_title": "International Journal of Infectious Diseases", "bibliographic_titleLang": "en"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Objective: The invasion of dengue virus (DENV)-2 Cosmopolitan genotype into the Philippines, where the Asian II genotype previously circulated challenges the principle of dengue serotype-specific immunity. Assessment of antibodies in this population may provide a mechanistic basis for how new genotypes emerge in dengue-endemic areas. Methods: We evaluated the neutralizing antibody (nAb) and antibody-dependent enhancement (ADE) responses against the two genotypes using archived serum samples collected from 333 patients with confirmed dengue in Metro Manila, Philippines, before, during, and after the introduction of the Cosmopolitan genotype. We quantified nAb titers in baby hamster kidney (BHK-21) cells with or without the Fcγ receptor IIA (Fcγ RIIA) to detect the capacity of virus-antibody complexes to neutralize or enhance DENV. Results: The nAb potency of the archived serum samples against the two genotypes was greatly affected by the presence of Fcγ RIIA. We found significant differences in nAb titers between the two genotypes in BHK-21 cells with Fcγ RIIA (P \u003c0.0 0 01). The archived serum samples were incapable of fully neutralizing the Cosmopolitan genotype, but instead strongly promoted its ADE compared to the Asian II genotype (P \u003c0.0 0 01). Conclusion: These results reinforce the role of pre-existing immunity in driving genotype shifts. Our finding that specific genotypes exhibit differing susceptibilities to ADE by cross-reactive antibodies may have implications for dengue vaccine development.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "International Journal of Infectious Diseases, 139, pp.59-68; 2023", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier B.V.", "subitem_publisher_language": "en"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.ijid.2023.11.025", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2023 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)", "subitem_rights_language": "en"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "12019712", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Balingit, Jean Claude", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Dimamay, Mark Pierre S.", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Suzuki, Ryosuke", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Matsuda, Mami", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Xayavong, Dalouny", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ngwe, Tun Mya Myat", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Matias, Ronald R.", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Natividad, Filipinas F.", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Moi, Meng Ling", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Takamatsu, Yuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Culleton, Richard", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Buerano, Corazon C.", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Morita, Kouichi", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2024-01-05"}], "download_preview_message": "", "file_order": 0, "filename": "IJID139_59.pdf", "filesize": [{"value": "3 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "application/pdf", "size": 3000000.0, "url": {"url": "https://nagasaki-u.repo.nii.ac.jp/record/2000489/files/IJID139_59.pdf"}, "version_id": "b5e0a534-9849-4237-9697-558c4106a378"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Dengue", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Antibody-dependent enhancement", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Genotype shift", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Neutralizing antibodies", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Pre-existing immunity", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Role of pre-existing immunity in driving the dengue virus serotype 2 genotype shift in the Philippines: A retrospective analysis of serological data", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Role of pre-existing immunity in driving the dengue virus serotype 2 genotype shift in the Philippines: A retrospective analysis of serological data", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "6", "path": ["36"], "permalink_uri": "http://hdl.handle.net/10069/0002000489", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2024-01-05"}, "publish_date": "2024-01-05", "publish_status": "0", "recid": "2000489", "relation": {}, "relation_version_is_last": true, "title": ["Role of pre-existing immunity in driving the dengue virus serotype 2 genotype shift in the Philippines: A retrospective analysis of serological data"], "weko_shared_id": -1}
Role of pre-existing immunity in driving the dengue virus serotype 2 genotype shift in the Philippines: A retrospective analysis of serological data
http://hdl.handle.net/10069/0002000489
http://hdl.handle.net/10069/0002000489