| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-02-06 |
| タイトル |
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|
タイトル |
A description of a pre-emptive typhoid Vi capsular polysaccharide vaccination campaign after the 2015 earthquake in Nepal and vaccine effectiveness evaluation |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Polysaccharide vaccine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Pre-emptive vaccination |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Typhoid |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Earthquake |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Nepal |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Dhoubhadel, Bhim Gopal
Sawada, Ikumi
Shrestha, Dhruba
Fukuya, Yoshifumi
Raya, Ganendra Bhakta
Nébié, Eric Ipyn
Hayashi, Yumiko
Pasakhala, Rasila
Suzuki, Motoi
Morimoto, Konosuke
Parry, Christopher M.
Ariyoshi, Koya
|
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Background: A 7.8 R scale earthquake hit Nepal in April 2015 and caused about 9000 deaths along with damage to infrastructure, including the water and sewage system. Bhaktapur was one of the highly afected districts. A typhoid vaccination campaign (pre-emptive) was carried out among children who were living in the temporary shelters in this district. The assessment of vaccine efectiveness after a pre-emptive typhoid vaccine campaign following an earthquake has previously not been attempted in Nepal. Objective To describe the pre-emptive typhoid Vi capsular polysaccharide vaccination campaign and an evaluation of the vaccine efectiveness. Methods: We conducted a pre-emptive typhoid Vi capsular polysaccharide vaccination campaign among children between 2 and 15 years of age dwelling in 23 temporary shelters in Bhaktapur district after the earthquake. Surveillance of clinical typhoid was carried out from 2014 to 2017 in Siddhi Memorial Hospital, the only hospital for children in the district. We calculated vaccine efectiveness using a case–control study design (clinical typhoid as cases and chest x-ray confrmed pneumonia as controls). Results: Three thousand nine hundred sixteen children of age 2–15 years residing in the 23 temporary shelters in Bhaktapur received the typhoid Vi capsular polysaccharide vaccine between July and December 2015. 2193 children of age 2–15 years were admitted to the hospital during the study period and 260 (11.9%) were diagnosed with clinical typhoid. The numbers of children admitted with clinical typhoid decreased over the study period (105 in 2014 and 47 in 2017; P=0.001). Overall vaccine efectiveness was calculated at 52% (95% CI −46 to 85%), and it was 87% (95% CI −25 to 99) among children less than 5 years of age. Conclusions: We successfully conducted a pre-emptive vaccination campaign against typhoid after the 2015 Nepal earthquake. The pre-emptive vaccination campaign appeared to be more efective among children less than 5 years of age. Further studies are needed to assess the efectiveness of pre-emptive use of typhoid vaccines in the emergency situations. We highlight the challenges of calculating vaccine efectiveness of a typhoid vaccine in an emergency setting. |
|
言語 |
en |
| 書誌情報 |
en : Tropical Medicine and Health
巻 52,
号 1,
p. art. no. 14,
発行日 2024-01-29
|
| 出版者 |
|
|
出版者 |
BioMed Central Ltd |
|
言語 |
en |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1349-4147 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1186/s41182-024-00580-w |
| 権利 |
|
|
言語 |
en |
|
権利情報 |
© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Tropical Medicine and Health, 52(1), art. no. 14; 2024 |
|
言語 |
en |
TMH52_14.pdf (980 KB)
