{"_buckets": {"deposit": "71581272-4ba1-4474-b368-98c1d0c69f9c"}, "_deposit": {"created_by": 6, "id": "2000596", "owner": "6", "owners": [6], "owners_ext": {"displayname": "学術コンテンツ担当(図書館員)", "username": "libcon_admin"}, "pid": {"revision_id": 0, "type": "depid", "value": "2000596"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:02000596", "sets": ["11"]}, "author_link": [], "control_number": "2000596", "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2024-02-08", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "art. no. 1343329", "bibliographicVolumeNumber": "12", "bibliographic_titles": [{"bibliographic_title": "Frontiers in Bioengineering and Biotechnology", "bibliographic_titleLang": "en"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Introduction: Dental erosion and abrasion pose significant clinical challenges, often leading to exposed dentinal tubules and dentine demineralization. The aim of this study was to analyse the efficacy of quercetin-encapsulated hollow mesoporous silica nanocomposites (Q@HMSNs) on the prevention of dentine erosion and abrasion. Method: Q@HMSNs were synthesized, characterized, and evaluated for their biocompatibility. A total of 130 dentine specimens (2 mm × 2 mm × 2 mm) were prepared and randomly distributed into 5 treatment groups (n = 26): DW (deionized water, negative control), NaF (12.3 mg/mL sodium fluoride, positive control), Q (300 μg/mL quercetin), HMSN (5.0 mg/mL HMSNs), and Q@HMSN (5.0 mg/mL Q@HMSNs). All groups were submitted to in vitro erosive (4 cycles/d) and abrasive (2 cycles/d) challenges for 7 days. The specimens in the DW, NaF, and Q groups were immersed in the respective solutions for 2 min, while treatment was performed for 30 s in the HMSN and Q@HMSN groups. Subsequently, the specimens were subjected to additional daily erosion/ abrasion cycles for another 7 days. The effects of the materials on dentinal tubule occlusion and demineralized organic matrix (DOM) preservation were examined by scanning electron microscopy (SEM). The penetration depth of rhodamine B fluorescein into the etched dentine was assessed using confocal laser scanning microscopy (CLSM). The erosive dentine loss (EDL) and release of type I collagen telopeptide (ICTP) were measured. The data were analysed by one-way analysis of variance (ANOVA) with post hoc Tukey’s test (α = 0.05). Results: Q@HMSNs were successfully synthesized and showed minimal toxicity to human dental pulp stem cells (HDPSCs) and gingival fibroblasts (HGFs). Q@ HMSNs effectively occluded the dentinal tubules, resulting in a thicker DOM in the Q@HMSN group. The CLSM images showed more superficial penetration in the HMSN and Q@HMSN groups than in the quercetin, NaF, and DW groups. The Q@ HMSN group exhibited a significantly lower EDL and reduced ICTP levels compared to the other groups (p \u003c 0.05). Conclusion: Q@HMSNs hold promise for inhibiting dentine erosion and abrasion by promoting tubule occlusion and DOM preservation.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Frontiers in Bioengineering and Biotechnology, 12, art. no. 1343329; 2024", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Frontiers Media S.A.", "subitem_publisher_language": "en"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.3389/fbioe.2024.1343329", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2024 Chen, Cheng, Yang, Su and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.", "subitem_rights_language": "en"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2296-4185", "subitem_source_identifier_type": "EISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Chen, Jia-Min", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Cheng, Yi-Ling", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yang, Meng-Hui", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Su, Chen", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yu, Hao", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2024-03-07"}], "download_preview_message": "", "file_order": 0, "filename": "FBB12_1343329.pdf", "filesize": [{"value": "4.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "application/pdf", "size": 4800000.0, "url": {"url": "https://nagasaki-u.repo.nii.ac.jp/record/2000596/files/FBB12_1343329.pdf"}, "version_id": "b2f08c6a-dcc1-4b47-9f23-4c9c0dd5f703"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "abrasion", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "demineralized organic matrix", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "erosion", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "hollow mesoporous silica", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "quercetin", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tubule occlusion", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Enhancing the inhibition of dental erosion and abrasion with quercetin-encapsulated hollow mesoporous silica nanocomposites", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Enhancing the inhibition of dental erosion and abrasion with quercetin-encapsulated hollow mesoporous silica nanocomposites", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "6", "path": ["11"], "permalink_uri": "http://hdl.handle.net/10069/0002000596", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2024-03-07"}, "publish_date": "2024-03-07", "publish_status": "0", "recid": "2000596", "relation": {}, "relation_version_is_last": true, "title": ["Enhancing the inhibition of dental erosion and abrasion with quercetin-encapsulated hollow mesoporous silica nanocomposites"], "weko_shared_id": -1}
Enhancing the inhibition of dental erosion and abrasion with quercetin-encapsulated hollow mesoporous silica nanocomposites
http://hdl.handle.net/10069/0002000596
http://hdl.handle.net/10069/0002000596