Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2024-03-11 |
タイトル |
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言語 |
en |
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タイトル |
PIVKA‑II is associated with liver function, bone metabolism, and muscle function in patients with liver disease |
言語 |
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言語 |
eng |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
PIVKA‑II |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
PT‑INR |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Child‑Pugh score |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
bone metabolic marker |
キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
SARC‑F |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
著者 |
Honda, Takuya
Ichikawa, Tatsuki
Yamashima, Mio
Yamamichi, Shinobu
Koike, Makiko
Nakano, Yusuke
Honda, Tetsurou
Yajima, Hiroyuki
Miyazaki, Osamu
Kuribayashi, Yasutaka
Ikeda, Tomonari
Okamura, Takuma
Nagata, Kazuyoshi
Nakao, Kazuhiko
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抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Protein induced by vitamin K (VK) absence‑II (PIVKA‑II) is a sensitive marker for diagnosing hepatoma but is occasionally detected in patients without hepatoma Here, the clinical significance of serum PIVKA‑II levels in patients who were not administered warfarin and did not have hepatoma or liver disease were evaluated. As VK is related to muscle and bone metabolism, PIVKA‑II and clinical factors related to bone and muscle were compared. A total of 441 patients with various liver diseases were evaluated. Of these, 236 patients were female. Clinical factors and anthropometric measurements were obtained for each participant during outpatient visits. Among the clinical factors, type I procollagen N‑propeptide (P1NP), a low titer of undercarboxylated osteocalcin (ucOC), and 25(OH) vitamin D (VD) were used as bone metabolic markers, and SARC‑F and grip strength were used as muscle‑related markers. Serum PIVKA‑II levels above the upper limit were associated with Child B/C (Child‑Pugh score), high titers of total P1NP, and low titers of ucOC in females, and alcohol‑related liver disease and low VD in males. The titer of PIVKA‑II were associated with immunoglobulin (Ig) A and prothrombin time (PT)‑international normalized ratio (INR) in females, and fibrosis‑4‑4, IgG, total bilirubin, PT‑INR, and SARC‑F in males. Elevated PIVKA‑II levels were associated with abnormal bone physiology in females, weak muscles in males, and severe liver disease in both sexes. Assessing PIVKA‑II may assist in evaluating the clinical and bone‑muscle metabolic stages in liver disease. Nutrition and supplementation with fat‑soluble vitamins, including VK and VD may thus serve as a potential method to alleviate or prevent bone‑muscle pathophysiology in patients with liver disease. |
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言語 |
en |
書誌情報 |
en : Biomedical Reports
巻 20,
号 1,
p. art. no. 2,
発行日 2023-11-13
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出版者 |
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言語 |
en |
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出版者 |
Spandidos Publications |
ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2049-9434 |
DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.3892/br.2023.1690 |
権利 |
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言語 |
en |
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権利情報 |
© 2023 Honda et al. This work is licensed under a Creative Commons Attribution- NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License. |
著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
引用 |
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内容記述タイプ |
Other |
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内容記述 |
Biomedical Reports, 20(1), art. no. 2; 2023 |
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言語 |
en |