WEKO3
アイテム
{"_buckets": {"deposit": "32524f28-eb48-42c2-8f22-33149e8da077"}, "_deposit": {"created_by": 6, "id": "2000738", "owner": "6", "owners": [6], "owners_ext": {"displayname": "学術コンテンツ担当(図書館員)", "username": "libcon_admin"}, "pid": {"revision_id": 0, "type": "depid", "value": "2000738"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:02000738", "sets": ["24"]}, "author_link": [], "control_number": "2000738", "item_5_alternative_title_19": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "新鮮ヒトamniotic membraneラッピングはPGAコラーゲンチューブの末梢神経再生能力を促進する", "subitem_alternative_title_language": "ja"}]}, "item_5_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2024-03-19", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "17", "bibliographicPageStart": "13", "bibliographicVolumeNumber": "58", "bibliographic_titles": [{"bibliographic_title": "Journal of plastic surgery and hand surgery", "bibliographic_titleLang": "en"}]}]}, "item_5_date_granted_64": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2024-03-19"}]}, "item_5_degree_grantor_62": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "Nagasaki University (長崎大学)"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "17301", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_5_degree_name_61": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士(医学)", "subitem_degreename_language": "ja"}]}, "item_5_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background: An artificial nerve conduit can interpose the peripheral nerve defect without donor site morbidity. However, treatment outcomes are often unsatisfactory. Human amniotic membrane (HAM) wrapping has been reported to promote peripheral nerve regeneration. We evaluated the effects of a combined application of fresh HAM wrapping and a polyglycolic acid tube filled with collagen (PGA-c) in a rat sciatic nerve 8-mm defect model. Methods: The rats were divided into three groups: (1) the PGA-c group (n = 5), in which the gap was interposed with the PGA-c; (2) the PGA-c/HAM group (n = 5), in which the gap was interposed with the PGA-c bridge, then HAM (14 × 7 mm) was wrapped around it; and (3) the Sham group (n = 5). Walking-Track recovery, electromyographic recovery, and histological recovery of the regenerated nerve were evaluated at 12 weeks postoperatively. Results: Compared to the PGA-c group, the PGA-c/HAM group showed significantly better recovery in terminal latency (3.4 ± 0.31 ms vs. 6.6 ± 0.72 ms, p \u003c 0.001), compound muscle action potential (0.19 ± 0.025 mV vs. 0.072 ± 0.027 mV, p \u003c 0.01), myelinated axon perimeter (15 ± 1.3 μm vs. 8.7 ± 0.63 μm, p \u003c 0.01), and g-ratio (0.69 ± 0.0089 vs. 0.78 ± 0.014, p \u003c 0.001). Conclusion: This combined application highly promotes peripheral nerve regeneration and may be more useful than PGA-c alone.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_5_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "長崎大学学位論文 学位記番号:博(医歯薬)甲第1564号 学位授与年月日:令和6年3月19日", "subitem_description_language": "ja", "subitem_description_type": "Other"}, {"subitem_description": "Author: Atsuhiko Iwao, Hiroto Saijo, Takafumi Nakayama, Akihito Higashi, Kazuya Kashiyama, Norisato Mitsutake and Katsumi Tanaka", "subitem_description_language": "en", "subitem_description_type": "Other"}, {"subitem_description": "Citation: Journal of plastic surgery and hand surgery, 58, pp.13-17; 2023", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_5_description_69": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Nagasaki University (長崎大学), 博士(医学) (2024-03-19)", "subitem_description_type": "Other"}]}, "item_5_dissertation_number_65": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲医歯薬第1564号"}]}, "item_5_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"names": [{"name": "Iwao, Atsuhiko", "nameLang": "en"}]}]}, "item_5_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Medical Journals Sweden", "subitem_publisher_language": "en"}]}, "item_5_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.2340/jphs.v58.6496", "subitem_relation_type_select": "DOI"}}]}, "item_5_relation_42": {"attribute_name": "関係URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://hdl.handle.net/10069/0002000617", "subitem_relation_type_select": "HDL"}}]}, "item_5_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2023 The Author(s). Published by Medical Journals Sweden on behalf of Acta Chirurgica Scandinavica. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/bync- nd/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.", "subitem_rights_language": "en"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2000-6764", "subitem_source_identifier_type": "EISSN"}]}, "item_5_text_67": {"attribute_name": "学位の種類", "attribute_value_mlt": [{"subitem_text_language": "ja", "subitem_text_value": "課程博士"}]}, "item_5_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "岩尾, 敦彦", "creatorNameLang": "ja"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2024-04-23"}], "download_preview_message": "", "file_order": 0, "filename": "ISYK1564_Iwao.pdf", "filesize": [{"value": "2.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "application/pdf", "size": 2400000.0, "url": {"objectType": "fulltext", "url": "https://nagasaki-u.repo.nii.ac.jp/record/2000738/files/ISYK1564_Iwao.pdf"}, "version_id": "934dba06-544b-412e-9f3a-6c19c54a668a"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Peripheral nerve regeneration", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "rat sciatic nerve defect model", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "human amniotic membrane", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "PGAcollagen tube", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Fresh human amniotic membrane wrapping promotes peripheral nerve regeneration in PGA-collagen tubes", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Fresh human amniotic membrane wrapping promotes peripheral nerve regeneration in PGA-collagen tubes", "subitem_title_language": "en"}]}, "item_type_id": "5", "owner": "6", "path": ["24"], "permalink_uri": "http://hdl.handle.net/10069/0002000738", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2024-04-23"}, "publish_date": "2024-04-23", "publish_status": "0", "recid": "2000738", "relation": {}, "relation_version_is_last": true, "title": ["Fresh human amniotic membrane wrapping promotes peripheral nerve regeneration in PGA-collagen tubes"], "weko_shared_id": -1}
Fresh human amniotic membrane wrapping promotes peripheral nerve regeneration in PGA-collagen tubes
http://hdl.handle.net/10069/0002000738
http://hdl.handle.net/10069/000200073802915d4a-0b19-4af9-9f85-439bac45d476
名前 / ファイル | ライセンス | アクション |
---|---|---|
ISYK1564_Iwao.pdf (2.4 MB)
|
|
Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
---|---|---|---|---|---|---|---|---|
公開日 | 2024-04-23 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Fresh human amniotic membrane wrapping promotes peripheral nerve regeneration in PGA-collagen tubes | |||||||
言語 | ||||||||
言語 | eng | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Peripheral nerve regeneration | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | rat sciatic nerve defect model | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | human amniotic membrane | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | PGAcollagen tube | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
資源タイプ | doctoral thesis | |||||||
アクセス権 | ||||||||
アクセス権 | open access | |||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
著者 |
岩尾, 敦彦
× 岩尾, 敦彦
|
|||||||
著者別名 | ||||||||
姓名 | Iwao, Atsuhiko | |||||||
言語 | en | |||||||
抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Background: An artificial nerve conduit can interpose the peripheral nerve defect without donor site morbidity. However, treatment outcomes are often unsatisfactory. Human amniotic membrane (HAM) wrapping has been reported to promote peripheral nerve regeneration. We evaluated the effects of a combined application of fresh HAM wrapping and a polyglycolic acid tube filled with collagen (PGA-c) in a rat sciatic nerve 8-mm defect model. Methods: The rats were divided into three groups: (1) the PGA-c group (n = 5), in which the gap was interposed with the PGA-c; (2) the PGA-c/HAM group (n = 5), in which the gap was interposed with the PGA-c bridge, then HAM (14 × 7 mm) was wrapped around it; and (3) the Sham group (n = 5). Walking-Track recovery, electromyographic recovery, and histological recovery of the regenerated nerve were evaluated at 12 weeks postoperatively. Results: Compared to the PGA-c group, the PGA-c/HAM group showed significantly better recovery in terminal latency (3.4 ± 0.31 ms vs. 6.6 ± 0.72 ms, p < 0.001), compound muscle action potential (0.19 ± 0.025 mV vs. 0.072 ± 0.027 mV, p < 0.01), myelinated axon perimeter (15 ± 1.3 μm vs. 8.7 ± 0.63 μm, p < 0.01), and g-ratio (0.69 ± 0.0089 vs. 0.78 ± 0.014, p < 0.001). Conclusion: This combined application highly promotes peripheral nerve regeneration and may be more useful than PGA-c alone. | |||||||
言語 | en | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第1564号 学位授与年月日:令和6年3月19日 | |||||||
言語 | ja | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Author: Atsuhiko Iwao, Hiroto Saijo, Takafumi Nakayama, Akihito Higashi, Kazuya Kashiyama, Norisato Mitsutake and Katsumi Tanaka | |||||||
言語 | en | |||||||
内容記述 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Citation: Journal of plastic surgery and hand surgery, 58, pp.13-17; 2023 | |||||||
言語 | en | |||||||
書誌情報 |
en : Journal of plastic surgery and hand surgery 巻 58, p. 13-17, 発行日 2024-03-19 |
|||||||
ISSN | ||||||||
収録物識別子タイプ | EISSN | |||||||
収録物識別子 | 2000-6764 | |||||||
DOI | ||||||||
関連タイプ | isIdenticalTo | |||||||
識別子タイプ | DOI | |||||||
関連識別子 | 10.2340/jphs.v58.6496 | |||||||
権利 | ||||||||
言語 | en | |||||||
権利情報 | © 2023 The Author(s). Published by Medical Journals Sweden on behalf of Acta Chirurgica Scandinavica. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/bync- nd/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work. | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
その他のタイトル | ||||||||
その他のタイトル | 新鮮ヒトamniotic membraneラッピングはPGAコラーゲンチューブの末梢神経再生能力を促進する | |||||||
言語 | ja | |||||||
出版者 | ||||||||
言語 | en | |||||||
出版者 | Medical Journals Sweden | |||||||
関係URI | ||||||||
識別子タイプ | HDL | |||||||
関連識別子 | http://hdl.handle.net/10069/0002000617 | |||||||
学位名 | ||||||||
言語 | ja | |||||||
学位名 | 博士(医学) | |||||||
学位授与機関 | ||||||||
学位授与機関識別子Scheme | kakenhi | |||||||
学位授与機関識別子 | 17301 | |||||||
言語 | ja | |||||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||||
学位授与年月日 | ||||||||
学位授与年月日 | 2024-03-19 | |||||||
学位授与番号 | ||||||||
学位授与番号 | 甲医歯薬第1564号 | |||||||
学位の種類 | ||||||||
ja | ||||||||
課程博士 | ||||||||
引用 | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2024-03-19) |