Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2024-05-07 |
タイトル |
|
|
言語 |
en |
|
タイトル |
Possible vertical transmission of Chikungunya virus infection detected in the cord blood samples from a birth cohort in Vietnam |
言語 |
|
|
言語 |
eng |
キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Chikungunya virus infection |
キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Vertical transmission |
キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Birth Cohort |
キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Vietnam |
資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
著者 |
Ngwe, Tun Mya Myat
Luvai, Elizabeth Ajema Chebichi
Toizumi, Michiko
Moriuchi, Masako
Takamatsu, Yuki
Inoue, Shingo
Urano, Takeshi
Bui, Minh Xuan
Thai, Hung Do
Thi, Nguyen Hien-Anh
Anh, Dang Duc
Yoshida, Lay-Myint
Moriuchi, Hiroyuki
Morita, Kouichi
|
抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Chikungunya virus (CHIKV) is an alphavirus (genus Alphavirus, family Togaviridae) that is primarily transmitted to humans by Aedes mosquitoes, and can be transmitted from mother to child. Little is known about CHIKV transmission in Vietnam, where dengue is endemic and Aedes mosquitoes are abundant. This study aimed to determine the prevalence and characteristics of vertical CHIKV infection in a birth cohort, and seroprevalence of anti-CHIKV antibodies with or without confirmation by neutralization tests among women bearing children in Vietnam. Methods: We collected umbilical cord blood plasma samples from each newly delivered baby in Nha Trang, Central Vietnam, between July 2017 and September 2018. Samples were subjected to molecular assay (quantitative real-time RT-PCR) and serological tests (anti-CHIKV IgM capture and IgG indirect enzyme-linked immunosorbent assay, and neutralization tests). Results: Of the 2012 tested cord blood samples from newly delivered babies, the HIKV viral genome was detected in 6 (0.3%) samples by RT-PCR, whereas, 15 samples (0.7%) were anti-CHIKV-IgM positive. Overall, 18 (0.9%, 95% CI: 0.6–1.5) samples, including three positives for both CHIKV IgM and viral genome on RT-PCR, were regarded as vertical transmission of CHIKV infection. Of the 2012 cord blood samples, 10 (0.5%, 95% CI: 0.2–0.9) were positive for both anti-CHIKV IgM and IgG. Twenty-nine (1.4%, 95% CI: 1.0–2.1) were seropositive for anti-CHIKV IgG while 26 (1.3%, 95% CI: 0.8–1.9) of them were also positive for neutralizing antibodies, and regarded as seropositive with neutralization against CHIKV infection. Conclusion: This is the first report of a possible CHIKV maternal-neonatal infection in a birth cohort in Vietnam. The findings indicate that follow-up and a differential diagnosis of CHIKV infection in pregnant women are needed to clarify the potential for CHIKV vertical transmission and its impact in the newborn. |
|
言語 |
en |
書誌情報 |
en : Journal of Infection and Public Health
巻 17,
号 6,
p. 1050-1056,
発行日 2024-04-29
|
出版者 |
|
|
言語 |
en |
|
出版者 |
Elsevier Ltd |
ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
18760341 |
DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.jiph.2024.04.012 |
権利 |
|
|
言語 |
en |
|
権利情報 |
© 2024 The Author(s). Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Journal of Infection and Public Health, 17(6), pp.1050-1056; 2024 |
|
言語 |
en |