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Single Lung Transplantation for the Treatment of Monocrotaline-Induced Pulmonary Hypertension in the Rat
http://hdl.handle.net/10069/16041
http://hdl.handle.net/10069/16041c2652de1-b7d0-4dbe-bcb3-22623898ee19
名前 / ファイル | ライセンス | アクション |
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acta40_01_09_t.pdf (986.3 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Single Lung Transplantation for the Treatment of Monocrotaline-Induced Pulmonary Hypertension in the Rat | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | monocrotaline | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | singlelung transplantation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pulmonary | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hypertension endothelin | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Yamamoto, Satoshi
× Yamamoto, Satoshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Hemodynamic effects and plasma endothelin concentration following single lung transplantation for pulmonary hypertension were studied in rats with monocrotalineinduced pulmonary hypertension. Inbred male Lewis rats (weight 200-300 g) were divided into two groups. In Group 1 (control group), rats underwent syngeneic left lung transplantation. In Group 2, rats received intravenous administration of monocrotaline (80 mg/kg) and 3 weeks later underwent syngeneic left single lung transplantation. Hemodynamic evaluations were performed prior to transplantation, and one hour, 3 and 7 days after transplantation. The rats were then killed and the heart and lungs were removed to measure the ventricular weight ratio (RV/LV+S), extravascular lung water volume (ELWV : dry/wet ratio), and for histologic examination. Mean pulmonary arterial pressure (m-PAP) rapidly declined after transplantation in Group 2, from 39.3±8.7 mmHg to 18.5±3.0 mmHg 1 hour after transplantation, similar to the control (Group 1) animals, and remained stable through day 7. There was no significant difference in the mean ELWV of grafted lungs between the two groups (0.84±0.03 vs. 0.86±0.04). The mean ELWV in the native lung of Group 2 animals significantly increased on day 3 (0.86±0.02) (p<0.01), but subsequently decreased to control values by day 7 (0.83±0.02). There was no significant difference in peripheral plasma endothelin levels between groups. These data demonstrate that monocrotaline-induced rat pulmonary hypertension does not affect plasma endothelin levels, and hemodynamic improvement can be obtained via single lung transplantation. We conclude that single lung transplantation is an effective modality for the treatment of pulmonary hypertension in the rat, and may eventually be useful in patients with advanced pulmonary hypertension. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 40, 号 1-4, p. 38-43, 発行日 1995-12-11 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00038-P00043 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1995, 40(1-4), p.38-43 |