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Studies of the Cell Proliferating Ability of Flat Type Colorectal Cancer by using CD44 Immunostaining Method and Double Staining Method of Ki67-AgNORs
http://hdl.handle.net/10069/16114
http://hdl.handle.net/10069/16114e0c120e9-a188-48e2-9f53-3763da60e917
名前 / ファイル | ライセンス | アクション |
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acta43_03_05_t.pdf (780.1 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Studies of the Cell Proliferating Ability of Flat Type Colorectal Cancer by using CD44 Immunostaining Method and Double Staining Method of Ki67-AgNORs | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | flat type colorectal cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD44 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ki67 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | AgNORs | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Nakamura, Shiro
× Nakamura, Shiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Author investigated the cell infiltrative activity, cell growth and cell proliferative activity of flat type colorectal cancer. Tissue specimens were obtained by surgery. These specimens were examined in expression of CD44 for the evaluation of cell infiltrative activity and Ki67 for growing cell, and then double-staining for AgNORs and Ki67 was performed to evaluate proliferative activity in growing cells. Analysis was performed by determining the labeling index (LI) of CD44 and Ki67, and the number of AgNORs in total 19 cases of type Is, type IIa, type IIa+IIc and type IIc. CD44 LI was 43% for type Is, 47% for type IIa, 55% for type IIa+IIc plus IIc, and a tendency of higher expression was presented in flat-elevated-with-depressed and flat-withdepressed tumors of type IIa+IIc plus IIc. Ki67 LI showed almost parallel data in three types. By double-staining method, the results of AgNORs counts in Ki67 negative cells were similar to those of Ki67 LI indicating that the proliferative activity was not different between tumors. In contrast, AgNORs counts in Ki67 positive cells were 8.48 in type Is, 7.67 in type IIa, and 10.75 in type IIa+IIc plus IIc, and the highest proliferative activity was presented in flatelevated- with-depressed and flat-with-depressed tumors of type IIa +IIc plus IIc. (p<0.05) Author's results suggest that the flat-elevated-with-depressed and flat-with-depressed tumor have a different characteristics compared with two types and is higher malignant and potentially invasive colorectal cancers than the other types. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 43, 号 3-4, p. 34-39, 発行日 1998-12-16 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00034-P00039 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1998, 43(3-4), p.34-39 |