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Pharmacological Comparison of Human Internal Mammary Artery and Radial Artery in Terms of Conduits for Revascularization
http://hdl.handle.net/10069/16168
http://hdl.handle.net/10069/1616847ac743d-3c98-4e82-a46d-5a76d5c5d41c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
acta45_03_06_t.pdf (534.5 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-03-13 | |||||
| タイトル | ||||||
| タイトル | Pharmacological Comparison of Human Internal Mammary Artery and Radial Artery in Terms of Conduits for Revascularization | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | human | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | internal mammary artery | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | radial artery | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | endothe lium function | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | coronary artery bypass grafting | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Yamaguchi, Koji
× Yamaguchi, Koji× Szlam, Fania× Levy, Jerrold H.× Makita, Tetsuji |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Internal mammary arteries (IMA) are routinely used for coronary artery bypass grafting (CABG), but can exhibit impairment of endothelium-dependent vascular relaxation. The use of radial artery (RA) grafts for CABG has been recently reintroduced. The long-term patency of these grafts may depend on the ability of these vessels to produce endotheliumderived nitric oxide (NO). We therefore sought to determine if the RA exhibits better endothelial function compared with IMA harvested from the same patient. Using the organ bath technique, vessels were preconstricted with the thromboxane A2 analogue (U46619) and exposed to increasing concentrations of either acetylcholine (ACh ), calcium ionophore A23187 (A23187), or nitroglycerin (NTG). We prepared the rubbed RA for comparison of between RA with and without endothelium on response to ACh relaxation. KCI and U46619 constricted RA (11.3ﾂｱ4.9g and 16.0ﾂｱ4.3g respectively) more than IMA(2.4ﾂｱ1.4g and 4.5ﾂｱ1.7 respectively). Both RA and IMA relaxed 100% of the preconstricted tension to NTG. ACh induced less relaxation in the IMA(28ﾂｱ24%) when compared with the RA(49ﾂｱ16%)(p<0.05). A23187 demonstrated relaxation in both the RA(86ﾂｱ14%)and IMA(76ﾂｱ18%), but there was no statistical difference. RA without endothelium showed same response to ACh as IMAs. Compared with the IMA, the RA has better ACh induced endothelium-dependent relaxation. This pathway mainly involves NO production which also inhibits the atherosclerotic process. Therefore, the RA may provide longer term graft patency than IMA. | |||||
| 書誌情報 |
Acta medica Nagasakiensia 巻 45, 号 3-4, p. 33-37, 発行日 2000-12-20 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00016055 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508430 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| sortkey | ||||||
| 値 | P00033-P00037 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Acta medica Nagasakiensia. 2000, 45(3-4), p.33-37 | |||||
