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Review Article Invasiveness of Pseudomonas aeruginosa and Its Role in Diversity of Pseudomonal Infectious Diseases
http://hdl.handle.net/10069/16217
http://hdl.handle.net/10069/162175b0dd263-dfef-4876-b50f-79fb3ffb8930
名前 / ファイル | ライセンス | アクション |
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acta47_03_02_t.pdf (1.0 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Review Article Invasiveness of Pseudomonas aeruginosa and Its Role in Diversity of Pseudomonal Infectious Diseases | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pseudomonas aeruginosa | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | invasiveness | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cytotoxicity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | multi-drug resistant efflux system | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Hirakata, Yoichi
× Hirakata, Yoichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Pseudomonas aeruginosa causes both invasive (bacteremic) and chronic non-invasive infections in several organs, resulting in the diversity of infectious diseases. When Madin- Darby canine kidney (MDCK) monolayers were infected with clinical isolates of P. aeruginosa, significantly (P < 0.001) more blood (30 of 32, 93.7%) than respiratory (25 of 45, 54.4%) isolates penetrated the epithelial cell monolayers by 3 h. Only eight (4 blood and 4 respiratory) isolates were cytotoxic and possessed exo U, and passed through the monolayer following epithelial cell death associated with release of lactose dehydrogenase and a marked drop in transepithelial electrical resistance. Thus, invasiveness was usually independent of cytotoxicity. The capacity to penetrate epithelial cells appears to be a critical determinant of invasiveness in susceptible hosts and may be controlled by unknown unique genes. In addition, such invasion determinant(s) are thought to be predominantly exported by P. aeruginosa via MexAB-OprM, which is one of multi-drug resistant (MDR) efflux systems. Hence, MDR efflux systems in P. aeruginosa might be critical for the efflux of virulence factors, in addition to their established role of exporting harmful substances such as antibiotics or detergents. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 47, 号 3-4, p. 89-96, 発行日 2002-12-17 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00089-P00096 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2002, 47(3-4), p.89-96 |