WEKO3
アイテム
{"_buckets": {"deposit": "58a17efd-2f4a-41b5-9366-ff3ee15cc6b1"}, "_deposit": {"created_by": 2, "id": "20769", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "20769"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00020769", "sets": ["28"]}, "author_link": ["87518"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2000-06-20", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "14", "bibliographicPageStart": "1", "bibliographicVolumeNumber": "5", "bibliographic_titles": [{"bibliographic_title": "Oral medicine \u0026 pathology"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Osteoblast differentiation is regulated by various hormones and local factors such as estrogen, parathyroid hormone, bone morphogenetic proteins (BMPs) and hedgehogs. Estrogen-deficiency increases systemic factors that stimulate osteoblast differentiation, resulting in a high turnover bone remodeling with accelerated bone formation. Parathyroid hormone has diverse effects on osteoblast differentiation depending on the exposure time in vitro mediated through different signal transduction systems. Among local factors, BMPs are the most potent inducers and stimulators of osteoblast differntiation: BMPs not only stimulate osteoprogenitors to differentiate into mature osteoblasts but also induce non-osteogenic cells to differntiate into osteoblast lineage cells. Sonic and Indian hedgehogs also play important roles in regulation of osteoblast differentiation by interacting with BMPs. Cbfal, a transcription factor belonging to the runt-domain gene family, is essential for osteoblast differentiation and bone formation because Cbfal-deficient mice completely lack bone formation due to maturational arrest of osteoblasts. BMPs are important local factors that up-regulate Cbfal expression. The phenotype of heterozygonus Cbfal mutation is similar to that of cleidocranial dysplasia. The intimate interaction between the local factors including hedgehogs and BMPs as well as the transcription factor Cbfal play crucial roles in the process of osteoblast differentiation and bone formation. Further progress in bone research will provide information important not only in the field of cell biology but also for clinical research of various bone diseases.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Oral medicine \u0026 pathology. 2000, 5(1), p.1-14", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "日本口腔病理学会"}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "日本口腔病理学会"}, {"subitem_rights": "本文データは学協会の許諾に基づきCiNiiから複製したものである"}]}, "item_2_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA11097826", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "13420984", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamaguchi, Akira"}], "nameIdentifiers": [{"nameIdentifier": "87518", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "OMP5_1_1.pdf", "filesize": [{"value": "2.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2800000.0, "url": {"label": "OMP5_1_1.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/20769/files/OMP5_1_1.pdf"}, "version_id": "7ce3aea9-263d-43ce-9034-563b57063fc3"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "osteoblast", "subitem_subject_scheme": "Other"}, {"subitem_subject": "bone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "estrogen", "subitem_subject_scheme": "Other"}, {"subitem_subject": "PTH", "subitem_subject_scheme": "Other"}, {"subitem_subject": "BMP", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Hedgehog", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Cbfal", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Regulatory Mechanism of Osteoblast Differentiation and Bone Formation", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Regulatory Mechanism of Osteoblast Differentiation and Bone Formation"}]}, "item_type_id": "2", "owner": "2", "path": ["28"], "permalink_uri": "http://hdl.handle.net/10069/16730", "pubdate": {"attribute_name": "公開日", "attribute_value": "2008-04-28"}, "publish_date": "2008-04-28", "publish_status": "0", "recid": "20769", "relation": {}, "relation_version_is_last": true, "title": ["Regulatory Mechanism of Osteoblast Differentiation and Bone Formation"], "weko_shared_id": -1}
Regulatory Mechanism of Osteoblast Differentiation and Bone Formation
http://hdl.handle.net/10069/16730
http://hdl.handle.net/10069/1673057f46cb3-178f-40e4-9800-57e5ae8153cd
名前 / ファイル | ライセンス | アクション |
---|---|---|
OMP5_1_1.pdf (2.8 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2008-04-28 | |||||
タイトル | ||||||
タイトル | Regulatory Mechanism of Osteoblast Differentiation and Bone Formation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | osteoblast | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | estrogen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PTH | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | BMP | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hedgehog | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cbfal | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamaguchi, Akira
× Yamaguchi, Akira |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Osteoblast differentiation is regulated by various hormones and local factors such as estrogen, parathyroid hormone, bone morphogenetic proteins (BMPs) and hedgehogs. Estrogen-deficiency increases systemic factors that stimulate osteoblast differentiation, resulting in a high turnover bone remodeling with accelerated bone formation. Parathyroid hormone has diverse effects on osteoblast differentiation depending on the exposure time in vitro mediated through different signal transduction systems. Among local factors, BMPs are the most potent inducers and stimulators of osteoblast differntiation: BMPs not only stimulate osteoprogenitors to differentiate into mature osteoblasts but also induce non-osteogenic cells to differntiate into osteoblast lineage cells. Sonic and Indian hedgehogs also play important roles in regulation of osteoblast differentiation by interacting with BMPs. Cbfal, a transcription factor belonging to the runt-domain gene family, is essential for osteoblast differentiation and bone formation because Cbfal-deficient mice completely lack bone formation due to maturational arrest of osteoblasts. BMPs are important local factors that up-regulate Cbfal expression. The phenotype of heterozygonus Cbfal mutation is similar to that of cleidocranial dysplasia. The intimate interaction between the local factors including hedgehogs and BMPs as well as the transcription factor Cbfal play crucial roles in the process of osteoblast differentiation and bone formation. Further progress in bone research will provide information important not only in the field of cell biology but also for clinical research of various bone diseases. | |||||
書誌情報 |
Oral medicine & pathology 巻 5, 号 1, p. 1-14, 発行日 2000-06-20 |
|||||
出版者 | ||||||
出版者 | 日本口腔病理学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13420984 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11097826 | |||||
権利 | ||||||
権利情報 | 日本口腔病理学会 | |||||
権利 | ||||||
権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Oral medicine & pathology. 2000, 5(1), p.1-14 |