WEKO3
アイテム
DHMEQ, a novel NF-kappaB inhibitor, suppresses growth and type I collagen accumulation in keloid fibroblasts
http://hdl.handle.net/10069/16875
http://hdl.handle.net/10069/16875296b8b7a-6d48-4cb7-a4d1-a4c076745807
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
JDS51_171.pdf (447.3 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-05-07 | |||||
| タイトル | ||||||
| タイトル | DHMEQ, a novel NF-kappaB inhibitor, suppresses growth and type I collagen accumulation in keloid fibroblasts | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Keloid | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NF-kappaB | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | DHMEQ | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Type I collagen | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Makino, Sachio
× Makino, Sachio× Mitsutake, Norisato× Nakashima, Masahiro× A., Saenko Vladimir× Ohtsuru, Akira× Umezawa, Kazuo× Tanaka, Katsumi× Hirano, Akiyoshi× Yamashita, Shunichi |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background:Keloid is a benign dermal tumor characterized by proliferation of dermal fibroblasts and overproduction of extracellular matrix (ECM). Nuclear factor kappaB (NF-κB) plays an important role in regulation of inflammation, immune response and cell proliferation. Activation of the NF-κB pathway is thought to be closely linked to abnormal cell proliferation and ECM production in keloid fibroblasts. Objective:This study was set out to investigate the effects of a novel selective NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), on keloid fibroblasts. Methods:Primary normal and keloid dermal fibroblasts were used for this study. NF-κB activity was assessed by DNA-binding assay and immunohistochemistry. The effect of DHMEQ was evaluated by cell viability, cell growth and type I collagen accumulation. Results:Basal NF-κB activity was constitutively elevated in keloid fibroblasts, indicating that this pathway is involved in keloid pathogenesis. DHMEQ markedly reduced cell proliferation and type I collagen accumulation in keloid fibroblasts. Conclusion:The inhibition of NF-κB by DHMEQ may be an attractive therapeutic approach for keloids. | |||||
| 書誌情報 | 号 3, p. 171-180, 発行日 2008-09 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 09231811 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11531842 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 18406579 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.jdermsci.2008.03.003 | |||||
| 権利 | ||||||
| 権利情報 | Copyright (c) 2008 Japanese Society for Investigative Dermatology Published by Elsevier Ireland Ltd. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Journal of Dermatological Science, 51(3), pp.171-180; 2008 | |||||
