| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-30 |
| タイトル |
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タイトル |
Negative impact of prior influenza vaccination on current influenza vaccination among people infected and not infected in prior season: A test-negative case-control study in Japan |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
主題 |
Influenza |
| キーワード |
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主題Scheme |
Other |
|
主題 |
Past influenza exposure |
| キーワード |
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主題Scheme |
Other |
|
主題 |
Repeated vaccination |
| キーワード |
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主題Scheme |
Other |
|
主題 |
Vaccine effectiveness |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Saito, Nobuo
Komori, Kazuhiro
Suzuki, Motoi
Morimoto, Kounosuke
Kishikawa, Takayuki
Yasaka, Takahiro
Ariyoshi, Koya
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background Accumulating evidences indicate that repeated influenza vaccination has negative impact on the vaccine effectiveness (VE). However no published studies considered past influenza infection when assessing the VE of repeated vaccination. Methods Prospective surveillance was conducted from 2009 to 2012 at a community hospital on a small island in Japan. The study included all outpatients with an influenza-like illness (ILI) who attended the hospital, and a rapid diagnostic test (RDT) was used to diagnose influenza A/B infection. The VE of trivalent inactivated influenza vaccine (TIV) against medically attended influenza A (MA-fluA) was estimated using a test-negative case-control study design. The influence of TIV in the prior season on VE in the current season was investigated in the context of MA-fluA during the prior season. Results During the three influenza seasons, 5838 ILI episodes (4127 subjects) were analysed. Subjects who had an episode of MA-fluA in the prior season were at a significantly lower risk of MA-fluA in the current season (adjusted odds ratio: 0.38, 95% CI: 0.30?0.50). The overall adjusted VE was 28% (95% CI, 14?40). VE was substantially lower in subjects vaccinated in the prior season compared to those who had not been vaccinated in prior season (19%; 95% CI: 0?35 vs 46%; 95% CI: 26?60, test for interaction, P value <0.05). In subjects who did not have MA-fluA in the prior season showed the attenuation of VE due to repeated vaccination (13%; 95% CI: ?7 to 30 vs 44%; 95% CI: 24?59, test for interaction, P < 0.05). However this effect was not detected in subjects who had contracted MA-fluA in the prior season. Conclusions Negative effects of repeated vaccination were significant among those without history of MA-fluA in the prior season. |
| 書誌情報 |
Vaccine
巻 35,
号 4,
p. 687-693,
発行日 2017-01-23
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| 出版者 |
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出版者 |
Elsevier Ltd |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0264410X |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.vaccine.2016.11.024 |
| 権利 |
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権利情報 |
c 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
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内容記述 |
Vaccine, 35(4), pp.687-693; 2017 |
Vaccine35_687.pdf (470.1 kB)
