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Morphological and Biochemical Evaluation of the Induction of Atherosclerosis in Japanese Quails
http://hdl.handle.net/10069/15818
http://hdl.handle.net/10069/158182d75b141-fb21-4805-90a7-aea503f52bb1
名前 / ファイル | ライセンス | アクション |
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acta35_01_18_t.pdf (1.1 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Morphological and Biochemical Evaluation of the Induction of Atherosclerosis in Japanese Quails | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Oku, Hirosuke
× Oku, Hirosuke× Toda, Takayoshi× Hamada, Yushi× Kiyuna, Masaya× Chinen, Isao× Toyomoto, Mari× Shinjo, Akihisa |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A total of 77 birds were divided into 7 groups which were fed the following diets : Group I, basal ; Group II, 5% corn oil (CO) + 0.5% cholesterol (CH) ; Group III, 5% CO + 2% CH; Group IV, 5% CO + 4% CH; Group V, 15% CO + 0.5% CH ; Group V I, 15% CO + 2% CH; Group VII, 15% CO + 4% CH. Significant increase of serum lipid, accumulation of lipid in the liver, and lipid-rich aortic lesions were produced in Groups IV, VI and VIII. However, hyperlipidemia correlated well with the extent of hepatic lipid accumulation and severity of aortic atherosclerosis in Group VI. Proliferating intimal cells showed positive reaction to antibodies for vimentin and alpha-1-antichymotrypsin implicating an important role of phenotypical transformation of intimal cells from the medial fibroblastic cells in the development of aortic atherosclerosis. These results suggest that Japanese quail is highly susceptible to atherosclerosis, and the optimal dietary level of cholesterol and corn oil is 2% and 15%, respectively to induce lipid-rich aortic lesions in Japanese quail. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 35, 号 1-4, p. 81-87, 発行日 1990-12-14 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00081-P00087 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1990, 35(1-4), p.81-87 |