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Immunolocalization of Adhesion Molecules in Rheumatoid and Osteoarthritic Synovial Tissues
http://hdl.handle.net/10069/15909
http://hdl.handle.net/10069/1590909c3466f-1e47-491e-9e4b-f2f9919b6291
名前 / ファイル | ライセンス | アクション |
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acta38_02_06_t.pdf (1.3 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Immunolocalization of Adhesion Molecules in Rheumatoid and Osteoarthritic Synovial Tissues | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rheumatoid arthritis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | osteoarthritis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | adhesion molecule | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | synovium. | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Aoyagi, Takahiko
× Aoyagi, Takahiko× Eguchi, Katsumi× Nakashima, Munetoshi× Ida, Hiroaki× Furuichi, Itaru× Maeda, Kenji× Nagataki, Shigenobu× Iwasaki, Katsuro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To elucidate the potential role of adhesion molecules in the pathogenesis of rheumatoid arthritis (RA), we stained specimens of synovial tissue from patients with RA and osteoarthritis (OA) with monoclonal antibodies against adhesion molecules using an immunohistochemical method. Positive staining with anti-ICAM-1 monoclonal antibody was detected on the synovial lining cells, the sublining cells and the capillary endothelial cells in the synovium from patients with RA, and, to a lesser degree, in that from patients with OA. The capillary endothelial cells from patients with RA intensively expressed both ELAM-1 and VLA-5α molecules, in contrast to that from OA patients. The intensity of both ICAM-1 and ELAM-1 on the capillary endothelial cells in RA synovium was comparable to disease activity and to the degree of synovial proliferation. A high density of expression of LFA-1α , VLA-4α and VLA-5α was observed on the mononuclear cells that infiltrated the RA synovium, especially in the lesions with aggregated mononuclear cells. The findings clearly demonstrated an up-regulation of the expression of adhesion molecules on synovial cells, capillary endothelial cells and infiltrated mononuclear cells in the synovial tissues of patients with RA. This enhanced expression of adhesion molecules may play an important role in the migration of mononuclear cells into the synovial tissues and thus perpetuate the inflammatory response in these tissues. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 38, 号 2-4, p. 62-70, 発行日 1993-12-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00062-P00070 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1993, 38(2-4), p.62-70 |