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Changes of Concentrations of Free Amino Acids in HeLa Cells Induced by Antitumor Agent
http://hdl.handle.net/10069/15952
http://hdl.handle.net/10069/159527b426c8d-d339-4c88-83c9-41ceb2b69519
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
acta38_02_49_t.pdf (453.3 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-03-13 | |||||
| タイトル | ||||||
| タイトル | Changes of Concentrations of Free Amino Acids in HeLa Cells Induced by Antitumor Agent | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Glutamine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Free amino acid | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Adriamycin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Amino acid imbalance | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Tagawa, Yutaka
× Tagawa, Yutaka× Mine, Yoshikazu× Yasutake, Toru× Matsuo, Satoshi× Tomita, Masao |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In this report we have investigated that the amino acid is most actively metabolized in the tumor cells damaged by antitumor agents, and discussed imbalanced amino acid procedure to be combined with cancer chemotherapy. The concentrations of 24 free amino acids in medium and in cells were determined in HeLa cells treated with Adriamycin. The free amino acids that decreased in the medium but increased in cells were glutamine and arginine. From this result, we treated HeLa cells with Adriamycin in medium of glutamine-deficiency and obtained a marked cytocidal effect. It would be difficult to make tumor tissues of glutamine-depletion in the whole body. For clinical application, local administration such as intraarterial infusion of L-glutamine antagonists combined with antitumor agents is expected as a practical administration method. | |||||
| 書誌情報 |
Acta medica Nagasakiensia 巻 38, 号 2-4, p. 265-269, 発行日 1993-12-25 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00016055 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508430 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| sortkey | ||||||
| 値 | P00265-P00269 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Acta medica Nagasakiensia. 1993, 38(2-4), p.265-269 | |||||
