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Human Monocytic Cells Upregulate Superoxide-Generating Activity and mRNAs for its Components in Response to Heat-Stable and Heat-Unstable Factors Released to Medium Conditioned with Ehrlichia Chaffeensis-Infected THP-1 Cells
http://hdl.handle.net/10069/9263
http://hdl.handle.net/10069/9263d077324a-5c8c-4248-9b3e-1c14a3b4ce94
名前 / ファイル | ライセンス | アクション |
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acta49_01_39.pdf (822.4 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-11-02 | |||||
タイトル | ||||||
タイトル | Human Monocytic Cells Upregulate Superoxide-Generating Activity and mRNAs for its Components in Response to Heat-Stable and Heat-Unstable Factors Released to Medium Conditioned with Ehrlichia Chaffeensis-Infected THP-1 Cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Superoxidegeneration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ehrlichiachaffeensis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | THP-1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MonocytesNADPHoxidase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Solublefactors | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Gunasekara, Deepa
× Gunasekara, Deepa× Fujii, Yoshito× Rusuvai, Erzsebet× Yoshiie, Kiyotaka× Ohashi, Norio× Nakamura, Michio |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To escape from reactive oxygen species generated in response to infection, intracellular pathogens, such as Salmonellae and Anaplasma phagocytophilum, can modulate the expression and distribution of the phagocyte NADPH oxidase components. In the present study, we analyzed the effect of Ehrlichia chaffeensis infection on the ability of human monocytic THP-1 cells to produce superoxide anion. Phorbol ester-stimulated superoxide generation and mRNAs for gp91phox, p47phox, and p67phox were significantly increased in E. chaffeensis-infected THP-1 cells. These increases were also achieved in THP-1 cells cultured in medium conditioned by the E. chaffeensis-infected cells, indicating that bystander cells can be activated for superoxide generation and implicating soluble factors in the response. Heat-stable and -unstable factors represented one-third and two-thirds of this activity, respectively. These results suggest that immature human monocytic cells increase their ability to generate superoxide anion in response to E. chaffeensis infection regardless they have been directly invaded or not. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 49, 号 1-2, p. 39-44, 発行日 2004-06 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/49.39 | |||||
sortkey | ||||||
P00039-P00044 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2004, 49(1-2), p.39-44 |