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Successful Treatment with Imatinib Mesylate of a Gastrointestinal Stromal Tumor with c-kit exon 11 Mutation
http://hdl.handle.net/10069/9268
http://hdl.handle.net/10069/926854d30380-819d-4284-adf1-7fbce74917c9
名前 / ファイル | ライセンス | アクション |
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acta49_01_63.pdf (821.6 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-11-02 | |||||
タイトル | ||||||
タイトル | Successful Treatment with Imatinib Mesylate of a Gastrointestinal Stromal Tumor with c-kit exon 11 Mutation | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gastrointestinalstromaltumor(GIST) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Imatinibmesylate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | c-kitmutation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Exon11 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Codon551-557 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Peritonealmetastasis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Yasutake, Toru
× Yasutake, Toru× Hidaka, Shigekazu× Tanaka, Kenji× Jibiki, Masa-Aki× Shibasaki, Shin-Ichi× Tsuji, Takashi× Nanashima, Atsushi× Sawai, Terumitsu× Yamaguchi, Hiroyuki× Nakagoe, Tohru× Nagayasu, Takeshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Gastrointestinal stromal tumors (GISTs) are common form of submucosal tumors of the stomach. Treatment of recurrent GISTs had been unsuccessful because of resistance to chemotherapy and radiotherapy. Recently, GISTs were reported to markedly respond to the molecular target agent, imatinib mesylate. We present here a patient with recurrent GIST and c-kit mutation who was successfully treated with imatinib mesylate. A 66-year-old man underwent partial gastrectomy because of GIST. The tumor was 3 cm in size and positive for KIT expression. One year after the excision, spiral computed tomography (CT) scan revealed four intra-peritoneal recurrence lesions measuring 7, 4, 3 and 2 cm in diameter. One week after the CT scan, we started treatment with imatinib mesylate at 400 mg/day, which resulted within two months in 40% decrease in the sum of the longest diameter. The reduction of tumor size continued for more than 6 months. Analysis of the c-kit mutation of the primary tumor revealed the deletion of 18 bases in exon 11 (codon 551-557), while other exons showed no mutation. In this report, we showed the effectiveness of imatinib mesylate therapy for the recurrence of GIST, especially with c-kit mutation in exon 11. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 49, 号 1-2, p. 63-66, 発行日 2004-06 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/49.63 | |||||
sortkey | ||||||
P00063-P00066 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2004, 49(1-2), p.63-66 |