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A Case of Large Cell Neuroendocrine Carcinoma of the Colon Responding to FOLFOX
http://hdl.handle.net/10069/9397
http://hdl.handle.net/10069/93978e378515-8064-411a-9077-188452229faf
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
acta52_02_67.pdf (1.3 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2007-11-02 | |||||
| タイトル | ||||||
| タイトル | A Case of Large Cell Neuroendocrine Carcinoma of the Colon Responding to FOLFOX | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Largecellneuroendocrinecarcinoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Colorectalcancer | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | FOLFOX | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
Susumu, Seiya
× Susumu, Seiya× Matsuo, Shigetoshi× Tsutsumi, Ryuji× Sugiyama, Nozomu× Azuma, Takashi× Yamaguchi, Satoshi× Kinoshita, Naoe× Hayashi, Tomayoshi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A 48-year-old woman was admitted to our hospital with abdominal fullness and pain. A barium enema and endoscopy revealed a Borrmann type II-like tumor of the sigmoid colon. Biopsy specimens showed poorly differentiated adenocarcinoma. Sigmoidectomy with lymph nodes dissection was performed. The tumor histologically consisted of proliferation of large and polygonal cells showing an organoid, trabecular or rosette-like pattern. Many mitotic figures were also observed. The tumor cells were immunohistochemically positive for chromogranin A. These findings led us to a diagnosis of large cell neuroendocrine carcinoma (LCNEC). Six months after surgery, liver metastases, para-aortic lymph node metastases and local recurrence were identified, and we commenced to administer FOLFOX, a combination of l-leucovorin and 5-fluorouracil with oxaliplatin. After six courses, a partial response was observed. This entity of the colon is not clearly recognized at present. The clinicopathological characteristics of LCNEC of the colon must be defined so that an appropriate treatment can be developed. Since LCNEC of the lung has been reported to be of high-grade malignancy, LCNEC of the colon must be treated as potentially highly malignant. In addition, the present case suggested that FOLFOX is a promising treatment for LCNEC of the colon. | |||||
| 書誌情報 |
Acta medica Nagasakiensia 巻 52, 号 2, p. 67-70, 発行日 2007-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00016055 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00508430 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関係URI | ||||||
| 関連名称 | http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/52.67 | |||||
| sortkey | ||||||
| 値 | P00067-P00070 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Acta medica Nagasakiensia. 2007, 52(2), p.67-70 | |||||
