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A Convenient Sublethal Assay of Alkylphenol and Organotin Compounds Using the Nematode Caenorhabditis elegans
http://hdl.handle.net/10069/8364
http://hdl.handle.net/10069/83640905ec4b-4e96-44ea-98c5-d98aff41f518
名前 / ファイル | ライセンス | アクション |
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JHS48_555.pdf (786.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-10-12 | |||||
タイトル | ||||||
タイトル | A Convenient Sublethal Assay of Alkylphenol and Organotin Compounds Using the Nematode Caenorhabditis elegans | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Caenorhabditis elegans | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | reproduction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | fecundity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hatching rate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | male expression | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | biosensor | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tominaga, Nobuaki
× Tominaga, Nobuaki× Tomoeda, Mineko× Kohra, Shinya× Takao, Yuji× Nagae, Masaki× Ueda, Kazuo× Ishibashi, Yasuhiro× Kai, Toshinori× Arizono, Koji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The free-living nematode, Caenorhabditis elegans (C. elegans) was adopted as a multicellular biosensor of biological toxicity from alkylphenols and organotin compounds. Alkylphenols were found to affect reproduction at lower doses than indicated by the acute toxicity assay. In particular, nonylphenol altered the reproduction rate of C. elegans at a dose 10- to 100-fold lower than the 50% lethal concentration (LC50). A comparison of the number of viable worms and eggs suggested that alkylphenols and organotin compounds possess hatching toxicity. A 0.1 μM dose of organotin compounds caused a significant decrease, in the order of 20-50%, in reproduction of the worms, and an abnormal male: hermaphrodite ratio was observed. C. elegans therefore appears to represent a potent and sensitive organism with which to evaluate the biological effects of chemicals. In particular, the sensitivity of reproduction as an endpoint is highly useful for assessing the sublethal effects of chemicals. | |||||
書誌情報 |
Journal of Health Science 巻 48, 号 6, p. 555-559, 発行日 2002-12 |
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出版者 | ||||||
出版者 | Pharmaceutical Society of Japan | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13449702 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1347-5207 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11316464 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/jhs.48.555 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://dx.doi.org/10.1248/jhs.48.555 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Health Science v.48(6) p.555-559, 2002 |