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Histopathological and immunohistochemical study in keratocystic odontogenic tumors: Predictive factors of recurrence
http://hdl.handle.net/10069/37543
http://hdl.handle.net/10069/375430734a822-1aa6-4a7b-9f1e-67c5f8db5091
名前 / ファイル | ライセンス | アクション |
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OncLet13_3487.pdf (1.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-06-09 | |||||
タイトル | ||||||
タイトル | Histopathological and immunohistochemical study in keratocystic odontogenic tumors: Predictive factors of recurrence | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cluster of differentiation 34 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Keratocystic odontogenic tumor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Marker of proliferation Ki-67 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Podoplanin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Recurrence | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Naruse, Tomofumi
× Naruse, Tomofumi× Yamashita, Kentaro× Yanamoto, Souichi× Rokutanda, Satoshi× Matsushita, Yuki× Sakamoto, Yuki× Sakamoto, Hiroshi× Ikeda, Hisazumi× Ikeda, Tohru× Asahina, Izumi× Umeda, Masahiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The aim of the present study was to identify the most useful markers for predicting recurrence of keratocystic odontogenic tumors (KCOTs). A total of 65 tumor samples from 63 patients diagnosed with typical parakeratinized cysts and KCOTs between 1992 and 2014 were retrospectively studied. Clinical and histopathological data and treatment modality were reviewed. In addition, the expression profiles of Ki-67, cluster of differentiation (CD)34 and podoplanin were assessed using immunohistochemistry. The association between these factors and the rate of KCOT recurrence was evaluated. The presence of daughter cysts, epithelial islands and high Ki-67, CD34 and podoplanin expression levels were revealed to be associated with tumor recurrence. In particular, univariate analysis revealed that high CD34 expression levels were significantly associated with tumor recurrence (P=0.034), as was conservative surgical treatment (P=0.003). Multivariate analysis revealed that conservative treatment was the greatest independent risk factor for tumor recurrence (odds ratio=13.337; P=0.018). These results suggest that overexpression of CD34 may be a potent predictor of tumor recurrence and radical treatment of the teeth that are in contact with the tumors is recommended in order to prevent tumor recurrence. | |||||
書誌情報 |
Oncology Letters 巻 13, 号 5, p. 3487-3493, 発行日 2017-05 |
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出版者 | ||||||
出版者 | Spandidos Publications | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 17921074 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 17921082 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3892/ol.2017.5905 | |||||
権利 | ||||||
権利情報 | c Naruse et al. This is an open access article distributed under the terms of Creative Commons Attribution License. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Oncology Letters, 13(5), pp.3487-3493; 2017 |