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Absorption of phenol red and bromphenol blue as model drugs from the peritoneal cavity around the liver surface in rats
http://hdl.handle.net/10069/6672
http://hdl.handle.net/10069/6672fb3c1279-e750-4fc7-8816-e2c0b75a2e18
名前 / ファイル | ライセンス | アクション |
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JPP47_1032.pdf (125.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-02-21 | |||||
タイトル | ||||||
タイトル | Absorption of phenol red and bromphenol blue as model drugs from the peritoneal cavity around the liver surface in rats | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nishida, Koyo
× Nishida, Koyo× Sato, Norihito× Sasaki, Hitoshi× Nakamura, Junzo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The effect of the injection site on the pharmacokinetics of phenol red and bromphenol blue as model drugs after intraperitoneal (i.p.) administration into rats was examined. Their absorption rate from the peritoneal cavity was faster after i.p. administration to the liver surface (LS) than that after i.p. administration to the distal small intestine (SI), as shown by the increase in maximum concentration and decrease in mean residence time in plasma. A similar tendency was observed in the biliary excretion pattern. The enhanced absorption rate was supported by the significantly smaller amount of both drugs remaining in the peritoneal cavity at 15 min after LS administration than that after SI administration. The liver concentration of the model drugs at 15 min after LS administration was 1.5 - 2.0 times higher than that after SI administration. Accordingly, LS administration was shown to be effective with good absorbability and efficient drug delivery to the liver. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | without figures | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | グラフなし | |||||
書誌情報 |
Journal of Pharmacy and Pharmacology 巻 47, 号 12A, p. 1032-1035, 発行日 1995-12 |
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出版者 | ||||||
出版者 | Pharmaceutical Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00223573 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00704643 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 8932690 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Pharmacy and Pharmacology, 47 (12A), 1032-1035, 1995 |