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Absorption characteristics of model compounds from the small intestinal serosal surface and a comparison with other organ surfaces
http://hdl.handle.net/10069/6678
http://hdl.handle.net/10069/6678b85ac1be-9222-472f-a9b4-c216bd555ad7
名前 / ファイル | ライセンス | アクション |
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JPP57_1073.pdf (138.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-02-21 | |||||
タイトル | ||||||
タイトル | Absorption characteristics of model compounds from the small intestinal serosal surface and a comparison with other organ surfaces | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nishida, Koyo
× Nishida, Koyo× Kuma, Akiko× Fumoto, Shintaro× Nakashima, Mikiro× Sasaki, Hitoshi× Nakamura, Junzo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We examined the absorption of phenolsulfonphthalein (PSP) and fluorescein isothiocyanate dextrans (FD-4, MW 4,400; FD-10, MW 9,500; FD-40, MW 40,500) as model compounds through the small intestinal serosal surface. After application to the rat small intestinal serosal surface using a cylindrical diffusion cell, each compound was absorbed at different rates. The absorption ratios in 6 h after PSP, FD-4, FD-10 and FD-40 application were calculated to be 89.2, 34.6, 14.9 and 2.1 % of dose, respectively. Elimination profiles of PSP, FD-4 and FD-10 from the small intestinal serosal surface obeyed first-order kinetics. Moreover, we calculated the apparent permeability coefficient Papp for comparison to other organ surfaces. The kidney had the highest absorption efficiency, as shown by having more than 1.5 times significantly higher Papp values of PSP, FD-4 and FD-10. Similar to the other organ surfaces, a correlation was observed between the Papp of small intestine and the molecular weight of these hydrophilic compounds. In addition, the small intestine is likely to contribute largely to hydrophilic compounds absorption from the peritoneal cavity, judging from absorption clearance CLa calculated by utilizing the peritoneal organ surface area. | |||||
書誌情報 |
Journal of Pharmacy and Pharmacology 巻 57, 号 8, p. 1073-1077, 発行日 2005-08 |
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出版者 | ||||||
出版者 | Pharmaceutical Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00223573 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00704643 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 16102265 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Pharmacy and Pharmacology, 57 (8), 1073-1077, 2005 |