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Clinical features and prognosis of patients with myelodysplastic syndromes who were exposed to atomic bomb radiation in Nagasaki
http://hdl.handle.net/10069/37571
http://hdl.handle.net/10069/37571f4420bce-8f24-4c01-b282-f0970e6a39d6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ISYK982_Matsuo.pdf (465.0 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-06-26 | |||||
| タイトル | ||||||
| タイトル | Clinical features and prognosis of patients with myelodysplastic syndromes who were exposed to atomic bomb radiation in Nagasaki | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Atomic bomb survivors | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | myelodysplastic syndromes | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | prognosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | radiation exposure | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | therapy-related myeloid neoplasms | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
松尾, 真稔
× 松尾, 真稔 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 115762 | |||||
| 姓名 | Matsuo, Masatoshi | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | There is evidence that radiation exposure is a causative factor of myelodysplastic syndromes (MDS). However, little is known about whether radiation exposure is also a prognostic factor of MDS. We investigated the impact of radiation exposure on the prognosis of MDS in Nagasaki atomic bomb survivors using the International Prognostic Scoring System (IPSS) and the revised version (IPSS-R). Subjects were 140 patients with primary MDS diagnosed between 1985 and 2011 and evaluable for IPSS, IPSS-R, and exposure distance. Of those, 31 were exposed at <1.5 km, 35 at 1.5?2.99 km, and 74 at ?3.0 km. By the end of March 2014, 47 patients (34%) progressed to overt leukemia and 106 (75.7%) died. By comparing with patients exposed at ?3.0 km, those exposed at <1.5 km had significantly higher frequencies of abnormal chromosome (P = 0.02), intermediate/poor IPSS, and intermediate/poor/very poor IPSS-R cytogenetic category (P = 0.0001, and P < 0.0001, respectively). As with de novo MDS, multivariate Cox regression analyses revealed that cytogenetic abnormalities, IPSS karyotype, and IPSS-R cytogenetics were significantly associated with poor survival, and cumulative incidence of leukemic transformation in MDS among atomic bomb survivors, but exposure distance was not associated with any poor outcomes. These suggest that exposure to the greater dose of atomic bomb radiation is associated with developing poor cytogenetic abnormalities in MDS, which might consequently lead to overt leukemia among atomic bomb survivors. |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第982号 学位授与年月日:平成29年6月7日 | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Author: Masatoshi Matsuo, Masako Iwanaga, Hisayoshi Kondo, Midori Soda, Tatsuro Jo, Kensuke Horio, Yumi Takasaki, Yasuhisa Kawaguchi, Hideki Tsushima, Yoshitaka Imaizumi, Daisuke Imanishi, Jun Taguchi, Yasushi Sawayama, Tomoko Hata and Yasushi Miyazaki | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Citation: Cancer Science, 107(10), pp.1484-1491; 2016 | |||||
| 書誌情報 |
Cancer Science 巻 107, 号 10, p. 1484-1491, 発行日 2017-06-07 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13479032 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/cas.13025 | |||||
| 権利 | ||||||
| 権利情報 | c 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. | |||||
| 権利 | ||||||
| 権利情報 | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is noncommercial and no modifications or adaptations are made. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| その他のタイトル | ||||||
| その他のタイトル | 長崎において原爆放射線に被ばくした骨髄異形成症候群患者の臨床的特徴と予後 | |||||
| 出版者 | ||||||
| 出版者 | John Wiley & Sons Australia, Ltd | |||||
| 学位名 | ||||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 17301 | |||||
| 学位授与機関名 | Nagasaki University (長崎大学) | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2017-06-07 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲医歯薬第982号 | |||||
| 学位の種類 | ||||||
| 値 | 課程博士 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Nagasaki University (長崎大学), 博士(医学) (2017-06-07) | |||||
