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サルモネラ症の化学療法に関する実験的研究 : 特にchloramphenicolの生体内における有効性について
http://hdl.handle.net/10069/4277
http://hdl.handle.net/10069/4277d04626a7-fc5c-40f1-a9e6-4271c0ba098f
名前 / ファイル | ライセンス | アクション |
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tm22_02_02_t.pdf (562.5 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-04-26 | |||||
タイトル | ||||||
タイトル | サルモネラ症の化学療法に関する実験的研究 : 特にchloramphenicolの生体内における有効性について | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
林, 敏明
× 林, 敏明× 岩永, 正明 |
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著者別名 | ||||||
姓名 | Hayashi, Toshiaki | |||||
著者別名 | ||||||
姓名 | Iwanaga, Masaaki | |||||
その他のタイトル | ||||||
その他のタイトル | Studies on the Antimicrobial Treatment of Experimental Salmonellosis : Effectiveness of Chloramphenicol in vivo and Its Mechanism | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In the antimicrobial treatment of salmonellosis, especially typhoid fever, no drug is clinically superior to chloramphenicol, although antibacterial effect of chloramphenicol in vitro is most inferior to other drugs. These facts were confirmed again in the present study using salmonellosis in C_<57>BL mice challenged orally with Salmonella typhimurium. To clarify the reason why chloramphenicol is so beneficial in the treatment of salmonellosis, a comparative study on chloramphenicol and amoxicillin was carried out using the experimental animals, in regards to distribution and duration of their activity in vivo, and the influence to bactericidal activity of the normal human serum. No significant difference between two drugs was found as far as the above regards were concerned. However, multiplication of challenged salmonella in the organs was markedly inhibited by the presence of chloramphenicol even in low concentration. | |||||
書誌情報 |
熱帯医学 Tropical medicine 巻 22, 号 2, p. 89-94, 発行日 1980-06-30 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03855643 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00199644 | |||||
出版者 | ||||||
出版者 | 長崎大学熱帯医学研究所 | |||||
出版者別言語 | ||||||
Institute of Tropical Medicine, Nagasaki University | ||||||
sortkey | ||||||
P00089-P00094 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 熱帯医学 Tropical medicine 22(2). p89-94, 1980 |