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Influence of Mannose and Its Derivatives on the Growth of Trypanosoma brucei gambiense in vitro
http://hdl.handle.net/10069/4536
http://hdl.handle.net/10069/45360169c603-e068-463b-9ce1-8b37a20db41c
名前 / ファイル | ライセンス | アクション |
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tm30_04_04_t.pdf (1.1 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-04-26 | |||||
タイトル | ||||||
タイトル | Influence of Mannose and Its Derivatives on the Growth of Trypanosoma brucei gambiense in vitro | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Mhando, Peter J.
× Mhando, Peter J.× Fukuma, Toshihide× Uemura, Haruki× Sooksri, Varunee× Kanbara, Hiroji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In the previous experiment mannose specifically inhibited the growth of blood trypomastigotes of Trypanosoma brucei gambiense in vitro over new born mouse brain cells. On the search of its mode of action, effect of mannose derivatives and other monosaccharides on the growth of trypanosomes both on feeder layer and feeder layer free systems was assayed. Different concentrations of each of the monosaccharides and mannose derivatives were added into culture media and used for the cultivation of trypanosomes. Most of the monosaccharides and mannose derivatives tested had no pronounced effect on the growth of the parasites, except α-D-(+)-mannose and 2-Deoxy-D-glucose which specifically inhibited the growth of bloodstream forms on feeder layer and feeder layer free cultures. Furthermore, transmission electron microscopy revealed denaturation of glycosomes, nuclei and kinetoplasts in those parasites cultured in medium containing α-D-(+)-mannose or 2-Deoxy-D-glucose. Nevertheless, surface coat, cell membrane and subpellicular microtubules were intact. Possible mode of action of mannose and 2-Deoxy-D-glucose is discussed. | |||||
書誌情報 |
熱帯医学 Tropical medicine 巻 30, 号 4, p. 251-256, 発行日 1988-12-28 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03855643 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00199644 | |||||
出版者 | ||||||
出版者 | 長崎大学熱帯医学研究所 | |||||
出版者別言語 | ||||||
Institute of Tropical Medicine, Nagasaki University | ||||||
sortkey | ||||||
P00251-P00256 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 熱帯医学 Tropical medicine 30(4). p251-256, 1988 |