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Effects of Heat Shock on Macrophage
http://hdl.handle.net/10069/4589
http://hdl.handle.net/10069/458943d81e75-4f51-40e3-a69b-a88b6182fcdb
名前 / ファイル | ライセンス | アクション |
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tm33_04_05_t.pdf (913.1 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-04-26 | |||||
タイトル | ||||||
タイトル | Effects of Heat Shock on Macrophage | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Lee, Jia-Ming
× Lee, Jia-Ming |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The macrophage plays an important role in lipopolysaccharide (LPS)-induced fever. Fever formation is attributed to macrophage activity. The purpose of this study was to examine whether induced fever has the characteristics of self-restriction during the process of a fever response. The result of methyl-[^3H]-thymidine incorporation in RAW 246.7 cells showed that the proliferation of the macrophage was suppressed by a heat load of 39℃ for 2 hr. Enzyme-linked immunosorbent assay (ELISA) showed that the activity of IL-1 secretion induced by LPS was also suppressed by heat load. Suppression of activities of the macrophage including proliferation and secretion suggest that negative feedback loops exist where the end product, heat, may act back on the macrophage and finally result in the subsiding of a fever. The induction of heat shock protein (hsp 70) by heat shock in the macrophage was detected by Western-blot and Northern-blot analysis. In U-937 cells, the increase of hsp 70 band appears to be related to the extent of inhibition of IL-1 secretion. It is assumed that IL-1 secretion from the macrophage which effects the induction of fever, has a close relationship to the induction of hsp 70. | |||||
書誌情報 |
熱帯医学 Tropical medicine 巻 33, 号 4, p. 135-143, 発行日 1991-12-20 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03855643 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00199644 | |||||
出版者 | ||||||
出版者 | 長崎大学熱帯医学研究所 | |||||
出版者別言語 | ||||||
Institute of Tropical Medicine, Nagasaki University | ||||||
sortkey | ||||||
P00135-P00143 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 熱帯医学 Tropical medicine 33(4). p135-143, 1991 |