| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2020-12-24 |
| タイトル |
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タイトル |
Congenital Zika Virus Infection in a Birth Cohort in Vietnam, 2017?2018 |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Ngwe, Tun Mya Myat
Moriuchi, Masako
Toizumi, Michiko
Luvai, Elizabeth
Raini, Sandra
Kitamura, Noriko
Takegata, Mizuki
Nguyen, Hien-Anh Thi
Moi, Meng Ling
Buerano, Corazon C.
Anh, Dang Duc
Yoshida, Lay-Myint
Morita, Kouichi
Moriuchi, Hiroyuki
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
To detect congenital ZIKV infection (CZI) in a birth cohort and among high-risk neonates in Vietnam, we collected umbilical cord blood plasma samples of newly delivered babies and peripheral plasma samples of high-risk neonates in Nha Trang, central Vietnam, between July 2017 and September 2018. Samples were subjected to serological and molecular tests. Of the 2013 newly delivered babies, 21 (1%) were positive for Zika virus (ZIKV) IgM and 1,599 (79%) for Flavivirus IgG. Among the 21 ZIKV IgM-positives, 11 were confirmed to have CZI because their plasma samples had anti-ZIKV neutralization titers 3 4 times higher than those against dengue virus (DENV)-1 to 4 and Japanese encephalitis virus (JEV) and were tested for the ZIKV RNA positive by real-time reverse transcription-PCR. Therefore,the incidence of CZI in our birth cohort was approximately 0.5%. Of the 150 high-risk neonates, three (2%) and 95 (63%) were positive for ZIKV IgM and Flavivirus IgG antibodies, respectively. None of the three ZIKV IgM-positives had 3 4 times higher anti-ZIKV neutralization
titers than those against DENV-1 to 4 and JEV, and were therefore considered as probable CZI. Our results indicate that CZI is not rare in Vietnam. Although those with confirmed CZI did not show apparent symptoms suspected of congenital Zika syndrome at birth, detailed examinations and follow-up studies are needed to clarify the CZI impact in Vietnam. This is the first report of CZI cases in a birth cohort in Asia. |
| 書誌情報 |
The American Journal of Tropical Medicine and Hygiene
巻 103,
号 5,
p. 2059-2064,
発行日 2020-08-17
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| 出版者 |
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出版者 |
American Society of Tropical Medicine and Hygiene |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00029637 |
| EISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
14761645 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.4269/ajtmh.20-0286 |
| 権利 |
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権利情報 |
c 2020 by The American Society of Tropical Medicine and Hygiene. This is an open-access article distributed under the terms of theCreative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
|
内容記述 |
American Journal of Tropical Medicine and Hygiene, 103(5), pp.2059-2064; 2020 |
AJTMH103_2059.pdf (101.5 kB)
