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Immunohistochemical Analysis of Histone H3 Modification in Newt Tail Tissue Cells following Amputation
http://hdl.handle.net/10069/00040518
http://hdl.handle.net/10069/0004051878b8f30c-61d0-4f99-bd44-55e3f86a3996
名前 / ファイル | ライセンス | アクション |
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SCI2021_8828931.pdf (3.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-02-22 | |||||
タイトル | ||||||
タイトル | Immunohistochemical Analysis of Histone H3 Modification in Newt Tail Tissue Cells following Amputation | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Wu, Ji-Wen
× Wu, Ji-Wen× Zhang, Xu× Sekiya, Reiko× Aoyagi, Kiyoshi× Li, Tao-Sheng |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background. Newts have impressive regenerative capabilities, but it remains unclear about the role of epigenetic regulation in regeneration process. We herein investigated histone modifications in newt tail tissue cells following amputation. Methods and Results. Iberian ribbed male newts (6-8 months old) were suffered to about 1.5 cm length of amputation of their tails for initiating regeneration process, and the residual stump of tail tissues was collected for immunohistochemical analysis 3 days later. Compared to the tissue cells of intact tails, c-kit-positive stem cells and PCNA-positive proliferating cells were significantly higher in tails suffered to amputation (P<0.001). Amputation also significantly induced the acetylation of H3K9, H3K14, and H3K27 in cells of the tails with amputation (P<0.001), but did not significantly change the methylation of H3K27 (P=0.063). Conclusion. These results suggest that epigenetic regulation likely involves in newt tail regeneration following amputation. | |||||
書誌情報 |
Stem Cells International 巻 2021, p. 8828931, 発行日 2021-01-06 |
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出版者 | ||||||
出版者 | Hindawi Limited | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1687-9678 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1155/2021/8828931 | |||||
権利 | ||||||
権利情報 | © 2021 Ji-Wen Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Stem Cells International, 2021, art.no.8828931; 2021 |