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Antimicrobial and immunomodulatory effects of tedizolid against methicillin-resistant Staphylococcus aureus in a murine model of hematogenous pulmonary infection
http://hdl.handle.net/10069/00040540
http://hdl.handle.net/10069/0004054085e8ab88-1e87-4603-8833-4d7e2fe8b452
名前 / ファイル | ライセンス | アクション |
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IJMM306_421.pdf (2.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-03-12 | |||||
タイトル | ||||||
タイトル | Antimicrobial and immunomodulatory effects of tedizolid against methicillin-resistant Staphylococcus aureus in a murine model of hematogenous pulmonary infection | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Methicillin-resistant Staphylococcus aureus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pulmonary infection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Murine model | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Oxazolidinone | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kaku, Norihito
× Kaku, Norihito× Morinaga, Yoshitomo× Takeda, Kazuaki× Kosai, Kosuke× Uno, Naoki× Hasegawa, Hiroo× Miyazaki, Taiga× Izumikawa, Koichi× Mukae, Hiroshi× Yanagihara, Katsunori |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Tedizolid (TZD) is a second-generation oxazolidinone and demonstrates potent in-vitro activity against multidrug-resistant Gram-positive bacteria. Phase III studies in patients with acute bacterial skin and skin structure infections (ABSSSI) have demonstrated the non-inferiority of TZD to linezolid (LZD). However, there are only a few studies that show the effect of TZD in pulmonary infections. In this study, we investigated the effect of TZD in a murine model of hematogenous pulmonary infection caused by methicillin-resistant Staphylococcus aureus (MRSA). The mice were treated either twice daily with saline (control), 25 mg/kg of vancomycin (low-VAN), 110 mg/kg of vancomycin (high-VAN), 120 mg/kg of LZD or once daily with 20 mg/kg of TZD. As compared to the control, the low- and high-VAN treatment groups, LZD and TZD significantly improved the survival rate, reduced the bacterial count in the lungs. Furthermore, TZD decreased the area of central bacterial colony zone (CBCZ) at 36 h post-inoculation, compared with the control. In addition, we investigated the immunomodulatory effect of TZD by evaluating the plasma concentrations of the inflammatory cytokines. Although there were no significant differences in the bacterial count in the lungs amongst the drugs at 26 h post-inoculation, TZD and LZD significantly improved the plasma concentrations of TNF-alpha, IL-6 and MIP-2, in comparison with the control. In this study, both TZD and LZD demonstrated antimicrobial and immunomodulatory efficacy in a murine model of hematogenous pulmonary infection caused by MRSA. | |||||
書誌情報 |
International Journal of Medical Microbiology 巻 306, 号 6, p. 421-428, 発行日 2016-09 |
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出版者 | ||||||
出版者 | Elsevier GmbH | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14384221 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ijmm.2016.05.010 | |||||
権利 | ||||||
権利情報 | © 2016 Elsevier GmbH. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Journal of Medical Microbiology, 306(6), pp.421-428; 2016 |