| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2019-12-19 |
| タイトル |
|
|
タイトル |
Efficacy of ethyl-EPA as a treatment for Huntington disease: a systematic review and meta-analysis |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
chorea |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
eicosapentaenoic acid |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Huntington disease |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
omega-3 fatty acids |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Morsy, Sara
Khalil, Samar Morsy
Doheim, Mohamed Fahmy
Kamel, Mohamed Gomaa
El-Basiony, Doaa Saeed Mahmoud
Ahmed, Hassan Hossam Idrees
Eisa, Ahmed Abdelaziz
Anh, Ngoc Cao Thị
Dang, Nguyen Phu
Hirayama, Kenji
Huy, Nguyen Tien
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
OBJECTIVE: After MRI studies suggested the efficacy of ethyl-EPA in reducing the progressive brain atrophy in Huntington disease (HD), trials were conducted to test its efficacy as a treatment for HD. Trials that continued for 6 months did not find any significant improvement, urging discontinuation of the drug. However, trials that continued for 12 months indicated improvement of motor functions in these patients. METHODS: We searched 12 electronic databases to find randomised clinical trials relevant to our inclusion criteria. After screening, only five papers were included. Continuous and binary variables were analysed to compute the pooled mean difference (MD) and risk ratio (RR), respectively. Quality effect model meta-analysis was used as a post hoc analysis for studies at 12 months. FINDINGS: Meta-analysis indicated that ethyl-eicosapentaenoic acid (EPA) has no significant effect on any scale of HD at 6 months. At 12 months, two studies suggested significant improvements of the Total Motor Score and Total Motor Score-4 in both fixed and quality effect models [MD = -2.720, 95% CI (-4.76, -.68), p = 0.009; MD = -2.225, 95% CI (-3.842, -0.607), p = 0.007], respectively. Maximal chorea score showed significant results [MD = -1.013, 95% CI (-1.793, -0.233), p = 0.011] in only fixed-effect model, while no improvement was detected for Stroop colour naming test or symbol digit modality. CONCLUSION: Meta-analysis indicated a significant improvement of motor scores only after 12 months. These results should be interpreted cautiously because only two studies had assessed the efficacy of ethyl-EPA after 12 months with one of them having a 6-month open-label phase. |
| 書誌情報 |
Acta Neuropsychiatrica
巻 31,
号 04,
p. 175-185,
発行日 2019-06-19
|
| 出版者 |
|
|
出版者 |
Cambridge University Press |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
09242708 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
16015215 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1017/neu.2019.11 |
| 権利 |
|
|
権利情報 |
c Scandinavian College of Neuropsychopharmacology 2019 |
| 権利 |
|
|
権利情報 |
This article has been published in a revised form in Acta neuropsychiatrica, http://doi.org/10.1017/neu.2019.11. This version is published under a Creative Commons CC-BY-NC-ND. No commercial re-distribution or re-use allowed. Derivative works cannot be distributed. |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Acta neuropsychiatrica, 31(4), pp.175-185; 2019 |
ANP31_175.pdf (2.4 MB)
