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The Effects of Wheel-Running Using the Upper Limbs Following Immobilization After Inducing Arthritis in the Knees of Rats
http://hdl.handle.net/10069/00040874
http://hdl.handle.net/10069/00040874f926ca6c-9a72-4ab9-895b-6b81f05313b5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PhysiolRes70_79.pdf (716.9 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2021-09-10 | |||||
| タイトル | ||||||
| タイトル | The Effects of Wheel-Running Using the Upper Limbs Following Immobilization After Inducing Arthritis in the Knees of Rats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Arthritis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Wheel-running exercise | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Immobilization | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Hyperalgesia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Central sensitization | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
TONG, Ying
× TONG, Ying× ISHIKAWA, Kumiko× SASAKI, Ryo× TAKESHITA, Izumi× SAKAMOTO, Junya× OKITA, Minoru |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | This study investigated the effects of wheel-running using the upper limbs following immobilization after inducing arthritis in the knees of rats. Forty male Wistar rats (aged 8 weeks) divided into four groups randomly: arthritis (AR), immobilization after arthritis (Im), wheel-running exercise with the upper limbs following immobilization after arthritis induction (Im+Ex) and sham arthritis induction (Con). The knee joints of the Im and Im+Ex groups were immobilized with a cast for 4 weeks. In the Im+Ex group, wheel-running exercise was administered for 60 min/day (5 times/week). The swelling and the pressure pain threshold (PPT) of the knee joint were evaluated for observing the condition of inflammatory symptoms in affected area, and the paw withdraw response (PWR) was evaluated for observing the condition of secondary hyperalgesia in distant area. Especially, in order to evaluate histological inflammation in the knee joint, the number of macrophage (CD68-positive cells) in the synovium was examined. The expression of calcitonin gene-related peptide (CGRP) in the spinal dorsal horn (L2-3 and L4-5) was examined to evaluate central sensitization. The Im+Ex group showed a significantly better recovery than the Im group in the swelling, PPTs, and PWRs. Additionally, CGRP expression of the spinal dorsal horn (L2-3 and L4-5) in the Im+Ex group was significantly decreased compared with the Im group. According to the results, upper limb exercise can decrease pain in the affected area, reduce hyperalgesia in distant areas, and suppress the central sensitization in the spinal dorsal horn by triggering exercise-induced hypoalgesia (EIH). | |||||
| 書誌情報 |
Physiological Research, 70 (1), pp. 79-87. 巻 70, 号 1, p. 79-87, 発行日 2021-03-17 |
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| 出版者 | ||||||
| 出版者 | Czech Academy of Sciences | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1802-9973 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 33453715 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.33549/physiolres.934469 | |||||
| 権利 | ||||||
| 権利情報 | © 2021 Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic. Physiological Research is an Open Access journal under the Creative Commons license (CC BY-NC-ND 4.0) | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Physiological Research, 70(1), pp. 79-87; 2021 | |||||
