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The acoustic characteristics of fine crackles predict honeycombing on high-resolution computed tomography
http://hdl.handle.net/10069/39428
http://hdl.handle.net/10069/39428d6e2e551-1538-4044-acba-9bc0dda785e1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
BMCPM19_153.pdf (717.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2019-09-05 | |||||
| タイトル | ||||||
| タイトル | The acoustic characteristics of fine crackles predict honeycombing on high-resolution computed tomography | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Fine crackles | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Frequency | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Honeycombing | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Lung sounds | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Onset timing | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Pulmonary fibrosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Time-expanded waveform analysis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Fukumitsu, Toshikazu
× Fukumitsu, Toshikazu× Obase, Yasushi× Ishimatsu, Yuji× Nakashima, Shota× Ishimoto, Hiroshi× Sakamoto, Noriho× Nishitsuji, Kosei× Shiwa, Shunpei× Sakai, Tomoya× Miyahara, Sueharu× Ashizawa, Kazuto× Mukae, Hiroshi× Kozu, Ryo |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Honeycombing on high-resolution computed tomography (HRCT) is a distinguishing feature of usual interstitial pneumonia and predictive of poor outcome in interstitial lung diseases (ILDs). Although fine crackles are common in ILD patients, the relationship between their acoustic features and honeycombing on HRCT has not been well characterized. Methods: Lung sounds were digitally recorded from 71 patients with fine crackles and ILD findings on chest HRCT. Lung sounds were analyzed by fast Fourier analysis using a sound spectrometer (Easy-LSA; Fukuoka, Japan). The relationships between the acoustic features of fine crackles in inspiration phases (onset timing, number, frequency parameters, and time-expanded waveform parameters) and honeycombing in HRCT were investigated using multivariate logistic regression analysis. Results: On analysis, the presence of honeycombing on HRCT was independently associated with onset timing (early vs. not early period; odds ratios [OR] 10.407, 95% confidence interval [95% CI] 1.366-79.298, P = 0.024), F99 value (the percentile frequency below which 99% of the total signal power is accumulated) (unit Hz = 100; OR 5.953, 95% CI 1.221-28.317, P = 0.029), and number of fine crackles in the inspiratory phase (unit number = 5; OR 4.256, 95% CI 1.098-16.507, P = 0.036). In the receiver-operating characteristic curves for number of crackles and F99 value, the cutoff levels for predicting the presence of honeycombing on HRCT were calculated as 13.2 (area under the curve [AUC], 0.913; sensitivity, 95.8%; specificity, 75.6%) and 752 Hz (AUC, 0.911; sensitivity, 91.7%; specificity, 85.2%), respectively. The multivariate logistic regression analysis additionally using these cutoff values revealed an independent association of number of fine crackles in the inspiratory phase, F99 value, and onset timing with the presence of honeycombing (OR 33.907, 95% CI 2.576-446.337, P = 0.007; OR 19.397, 95% CI 2.311-162.813, P = 0.006; and OR 12.383, 95% CI 1.443-106.293, P = 0.022; respectively). Conclusions: The acoustic properties of fine crackles distinguish the honeycombing from the non-honeycombing group. Furthermore, onset timing, number of crackles in the inspiratory phase, and F99 value of fine crackles were independently associated with the presence of honeycombing on HRCT. Thus, auscultation routinely performed in clinical settings combined with a respiratory sound analysis may be predictive of the presence of honeycombing on HRCT. | |||||
| 書誌情報 |
BMC Pulmonary Medicine 巻 19, 号 1, p. 153, 発行日 2019-08-17 |
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| 出版者 | ||||||
| 出版者 | BioMed Central Ltd. | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 14712466 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1186/s12890-019-0916-5 | |||||
| 権利 | ||||||
| 権利情報 | c The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | BMC Pulmonary Medicine, 19(1), art.no.153; 2019 | |||||
