Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2021-09-24 |
タイトル |
|
|
タイトル |
Identification of potential novel hosts and the risk of infection with lymphocytic choriomeningitis virus in humans in Gabon, Central Africa |
言語 |
|
|
言語 |
eng |
キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Lymphocytic choriomeningitis virus |
キーワード |
|
|
主題Scheme |
Other |
|
主題 |
LCMV |
キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Prevalence |
キーワード |
|
|
主題Scheme |
Other |
キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Gabon |
キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Africa |
資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
著者 |
Ushijima, Yuri
Abe, Haruka
Ozeki, Takehiro
Ondo, Georgelin N.
Mbadinga, Marien J.V.M.
Bikangui, Rodrigue
Nze-Nkogue, Chimène
Akomo-Okoue, Etienne F.
Ella, Ghislain W.E.
Koumba, Lilian B.M.
Nso, Branly C.B.B.
Mintsa-Nguema, Rodrigue
Makouloutou-Nzassi, Patrice
Makanga, Boris K.
Nguelet, Fred L.M.
Zadeh, Vahid R.
Urata, Shuzo
Mbouna, Armel V.N.
Massinga-Loembe, Marguerite
Agnandji, Selidji T.
Lell, Bertrand
Yasuda, Jiro
|
抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Objectives: Lymphocytic choriomeningitis virus (LCMV), a human pathogenic arenavirus, is distributed worldwide. However, no human cases have been reported in Africa. This study aimed to investigate the current situation and potential risks of LCMV infection in Gabon, Central Africa. Methods: A total of 492 human samples were screened to detect LCMV genome RNA and anti-LCMV IgG antibodies using reverse transcription-quantitative PCR and enzyme-linked immunosorbent assay (ELISA), respectively. ELISA-positive samples were further examined using a neutralization assay. Viral RNAs and antibodies were also analyzed in 326 animal samples, including rodents, shrews, and bushmeat. Results: While no LCMV RNA was detected in human samples, the overall seroprevalence was 21.5% and was significantly higher in male and adult populations. The neutralization assay identified seven samples with neutralizing activity. LCMV RNA was detected in one species of rodent (Lophuromys sikapusi) and a porcupine, and anti-LCMV IgG antibodies were detected in four rodents and three shrews. Conclusions: This study determined for the first time the seroprevalence of LCMV in Gabon, and revealed that local rodents, shrews, and porcupines in areas surrounding semi-urban cities posed an infection risk. Hence, LCMV infection should be considered a significant public health concern in Africa. |
書誌情報 |
International Journal of Infectious Diseases
巻 105,
p. 452-459,
発行日 2021-03-02
|
出版者 |
|
|
出版者 |
Elsevier Ltd |
ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1201-9712 |
DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.ijid.2021.02.105 |
権利 |
|
|
権利情報 |
© 2021 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
引用 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
International Journal of Infectious Diseases, 105, pp. 452-459; 2021 |