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The Antiviral Effect of the Chemical Compounds Targeting DED/EDh Motifs of the Viral Proteins on Lymphocytic Choriomeningitis Virus and SARS-CoV-2
http://hdl.handle.net/10069/00041021
http://hdl.handle.net/10069/00041021f81cd9c9-6b02-46f8-bb7d-df07297d1127
名前 / ファイル | ライセンス | アクション |
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Viruses13_1220.pdf (1.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-11-12 | |||||
タイトル | ||||||
タイトル | The Antiviral Effect of the Chemical Compounds Targeting DED/EDh Motifs of the Viral Proteins on Lymphocytic Choriomeningitis Virus and SARS-CoV-2 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lymphocytic choriomeningitis virus (LCMV) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | SARS-CoV-2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | antivirals | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | exonuclease (ExoN) motif | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DED/EDh motif | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ngwe Tun, Mya Myat
× Ngwe Tun, Mya Myat× Morita, Kouichi× Ishikawa, Takeshi× Urata, Shuzo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Arenaviruses and coronaviruses include several human pathogenic viruses, such as Lassa virus, Lymphocytic choriomeningitis virus (LCMV), SARS-CoV, MERS-CoV, and SARS-CoV-2. Although these viruses belong to different virus families, they possess a common motif, the DED/EDh motif, known as an exonuclease (ExoN) motif. In this study, proof-of-concept studies, in which the DED/EDh motif in these viral proteins, NP for arenaviruses, and nsp14 for coronaviruses, could be a drug target, were performed. Docking simulation studies between two structurally different chemical compounds, ATA and PV6R, and the DED/EDh motifs in these viral proteins indicated that these compounds target DED/EDh motifs. The concentration which exhibited modest cell toxicity was used with these compounds to treat LCMV and SARS-CoV-2 infections in two different cell lines, A549 and Vero 76 cells. Both ATA and PV6R inhibited the post-entry step of LCMV and SARS-CoV-2 infection. These studies strongly suggest that DED/EDh motifs in these viral proteins could be a drug target to combat two distinct viral families, arenaviruses and coronaviruses. | |||||
書誌情報 |
Viruses 巻 13, 号 7, p. 1220, 発行日 2021-06-24 |
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出版者 | ||||||
出版者 | MDPI | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1999-4915 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/v13071220 | |||||
権利 | ||||||
権利情報 | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Viruses, 13(7), art. no. 1220; 2021 |