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Induction of mucosal immunity by pulmonary administration of a cell-targeting nanoparticle
http://hdl.handle.net/10069/00041041
http://hdl.handle.net/10069/0004104187e9c72a-5fe7-45a8-89e8-519d7f513d35
名前 / ファイル | ライセンス | アクション |
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DD28_1585.pdf (2.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-11-19 | |||||
タイトル | ||||||
タイトル | Induction of mucosal immunity by pulmonary administration of a cell-targeting nanoparticle | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Vaccine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pulmonary administration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nanoparticles | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | γ-polyglutamic acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mucosal immunity | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kurosaki, Tomoaki
× Kurosaki, Tomoaki× Katafuchi, Yuki× Hashizume, Junya× Harasawa, Hitomi× Nakagawa, Hiroo× Nakashima, Mikiro× Nakamura, Tadahiro× Yamashita, Chikamasa× Sasaki, Hitoshi× Kodama, Yukinobu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We previously found that a nanoparticle constructed with an antigen, benzalkonium chloride (BK) and γ-polyglutamic acid (γ-PGA) showed high Th1 and Th2-type immune induction after subcutaneous administration. For prophylaxis of respiratory infections, however, mucosal immunity should be induced. In this study, we investigated the effect of pulmonary administration of a nanoparticle comprising ovalbumin (OVA) as a model antigen, BK, and γ-PGA on induction of mucosal immunity in the lungs and serum. The complex was strongly taken up by RAW264.7 and DC2.4cells. After pulmonary administration, lung retention was longer for the OVA/BK/γ-PGA complex than for OVA alone. OVA-specific serum immunoglobulin (Ig)G was highly induced by the complex. High IgG and IgA levels were also induced in the bronchoalveolar lavage fluid, and in vivo toxicities were not observed. In conclusion, we effectively and safely induced mucosal immunity by pulmonary administration of an OVA/BK/γ-PGA complex. | |||||
書誌情報 |
Drug Delivery 巻 28, 号 1, p. 1585-1593, 発行日 2021-07-22 |
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出版者 | ||||||
出版者 | Taylor and Francis Ltd. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1071-7544 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1080/10717544.2021.1955040 | |||||
権利 | ||||||
権利情報 | © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Drug Delivery, 28(1), pp. 1585-1593; 2021 |