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Tetrodotoxin/Saxitoxins Selectivity of the Euryhaline Freshwater Pufferfish Dichotomyctere fluviatilis
http://hdl.handle.net/10069/00041115
http://hdl.handle.net/10069/0004111530f29477-f9d8-43dc-aed4-a410b2c48544
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Toxins13_731.pdf (1.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-12-21 | |||||
| タイトル | ||||||
| タイトル | Tetrodotoxin/Saxitoxins Selectivity of the Euryhaline Freshwater Pufferfish Dichotomyctere fluviatilis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Dichotomyctere fluviatilis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | pufferfish | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | saxitoxin (STX) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Takifugu rubripes | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | tetrodotoxin (TTX) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | tissue slice | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Zhu, Hongchen
× Zhu, Hongchen× Sakai, Towa× Nagashima, Yuji× Doi, Hiroyuki× Takatani, Tomohiro× Arakawa, Osamu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The present study evaluated differences in the tetrodotoxin (TTX)/saxitoxins (STXs) selectivity between marine and freshwater pufferfish by performing in vivo and in vitro experiments. In the in vivo experiment, artificially reared nontoxic euryhaline freshwater pufferfish Dichotomyctere fluviatilis were intrarectally administered a mixture of TTX (24 nmol/fish) and STX (20 nmol/fish). The amount of toxin in the intestine, liver, muscle, gonads, and skin was quantified at 24, 48, and 72 h. STX was detected in the intestine over a long period of time, with some (2.7–6.1% of the given dose) being absorbed into the body and temporarily located in the liver. Very little TTX was retained in the body. In the in vitro experiments, slices of intestine, liver, and skin tissue prepared from artificially reared nontoxic D. fluviatilis and the marine pufferfish Takifugu rubripes were incubated in buffer containing TTX and STXs (20 nmol/mL each) for up to 24 or 72 h, and the amount of toxin taken up in the tissue was quantified over time. In contrast to T. rubripes, the intestine, liver, and skin tissues of D. fluviatilis selectively took up only STXs. These findings indicate that the TTX/STXs selectivity differs between freshwater and marine pufferfish. | |||||
| 書誌情報 |
Toxins 巻 13, 号 10, p. 731, 発行日 2021-10-16 |
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| 出版者 | ||||||
| 出版者 | MDPI | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2072-6651 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/toxins13100731 | |||||
| 権利 | ||||||
| 権利情報 | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Toxins, 13(10), art. no. 731; 2021 | |||||
