| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-01-24 |
| タイトル |
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|
タイトル |
The BRAFV600E Mutation Is Not a Risk Factor for More Aggressive Tumor Behavior in Radiogenic and Sporadic Papillary Thyroid Carcinoma at a Young Age |
| 言語 |
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|
言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
主題 |
papillary thyroid carcinoma |
| キーワード |
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主題Scheme |
Other |
|
主題 |
BRAFV600E |
| キーワード |
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主題Scheme |
Other |
|
主題 |
Chernobyl |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
immunohistochemistry |
| キーワード |
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主題Scheme |
Other |
|
主題 |
VE1 antibody |
| キーワード |
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主題Scheme |
Other |
|
主題 |
Ki67 labeling index |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Zurnadzhy, Liudmyla
Bogdanova, Tetiana
Rogounovitch, Tatiana I.
Ito, Masahiro
Tronko, Mykola
Yamashita, Shunichi
Mitsutake, Norisato
Chernyshov, Serhii
Masiuk, Sergii
Saenko, Vladimir A.
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Histopathological changes in the fusion oncogene-driven papillary thyroid carcinomas (PTCs) from children and adolescents exposed to Chernobyl fallout have been extensively studied. However, characteristics of the radiogenic BRAFV600E-positive PTCs, whose proportion is growing with time, are not well described yet. We analyzed the relationship between the BRAFV600E status (determined immunohistochemically with the VE1 antibody) and the clinicopathological features of 247 radiogenic and 138 sporadic PTCs from young Ukrainian patients aged ≤28 years. The frequency of BRAFV600E was increasing with patient age, consistently remaining lower in radiogenic PTCs. In both etiopathogenic groups, the BRAFV600E-positive PTCs more frequently had a dominant papillary growth pattern, smaller tumor size, higher Ki67 labeling index, and a frequency of the major indicators of tumor invasiveness that is lower than or equal to that of the BRAFV600E-negative tumors. Comparison of the BRAFV600E-positive PTCs across the groups found a virtual absence of differences. In contrast, the BRAFV600E-negative radiogenic PTCs displayed less frequent dominant papillary and more frequent solid growth patterns, lower Ki67 labeling index, and higher invasiveness than the BRAFV600E-negative sporadic tumors. Thus, BRAFV600E is not associated with a more aggressive course of PTC in young patients regardless of etiology. The major clinicopathological differences between the radiogenic and sporadic PTCs are observed among the BRAFV600E-negative tumors. |
| 書誌情報 |
Cancers
巻 13,
号 23,
p. 6038,
発行日 2021-11-30
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| 出版者 |
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出版者 |
MDPI |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2072-6694 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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|
関連識別子 |
10.3390/cancers13236038 |
| 権利 |
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|
権利情報 |
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 引用 |
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内容記述タイプ |
Other |
|
内容記述 |
Cancers, 13(23), art. no. 6038; 2021 |
Cancers13_6038.pdf (1.3 MB)
