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Biological Differences Between Ovarian Cancer-associated Fibroblasts and Contralateral Normal Ovary-derived Mesenchymal Stem Cells
http://hdl.handle.net/10069/00041395
http://hdl.handle.net/10069/0004139582e94ae4-ad15-44ec-a922-d790ec6e5876
名前 / ファイル | ライセンス | アクション |
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AR42_1729.pdf (3.0 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-04-15 | |||||
タイトル | ||||||
タイトル | Biological Differences Between Ovarian Cancer-associated Fibroblasts and Contralateral Normal Ovary-derived Mesenchymal Stem Cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cancer-associated fibroblasts | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ovarian cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | stromalcells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mesenchymal stem cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | normal ovary | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
OHASHI, KAZUAKI
× OHASHI, KAZUAKI× LI, TAO-SHENG× MIURA, SHOKO× HASEGAWA, YURI× MIURA, KIYONORI |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background/Aim: The aim of this study was to clarify the biological differences between ovarian cancerassociated fibroblasts (OCa-CAFs) and normal ovary-derived mesenchymal stem cells (NO-MSCs). Materials and Methods: Surgically resected ovarian cancer and contralateral normal ovarian tissue samples were cut into small pieces for culture as “explants”. The number of outgrown cells, their proliferative kinetics, and expression levels of cell surface markers of CAFs, as well as three miRNAs in OCa-CAFs and NO-MSCs were compared directly. Differentially expressed genes between both groups were also investigated. Results: Comparable numbers of outgrown cells were harvested from both groups. Significantly higher expression of α-smooth muscle actin and miR-142 was found in OCa-CAFs, which decreased significantly during ex vivo cell expansion. A total of 21 differentially expressed genes were identified between both groups. Conclusion: OCa-CAFs showed different biological properties in direct comparison with NO-MSCs, which might play major roles in the pathogenesis of ovarian cancer. | |||||
書誌情報 |
Anticancer Research 巻 42, 号 4, p. 1729-1737, 発行日 2022-03-28 |
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出版者 | ||||||
出版者 | International Institute of Anticancer Research | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0250-7005 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.21873/anticanres.15649 | |||||
権利 | ||||||
権利情報 | Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Anticancer Research, 42(4), pp.1729-1737; 2022 |