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A turn-on hydrazide oxidative decomposition-based fluorescence probe for highly selective detection of Cu2+ in tap water as well as cell imaging
http://hdl.handle.net/10069/00041608
http://hdl.handle.net/10069/00041608241d4902-52ce-4aa4-914a-80383d47595e
名前 / ファイル | ライセンス | アクション |
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ACA1217_340024.pdf (1.7 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-07-14 | |||||
タイトル | ||||||
タイトル | A turn-on hydrazide oxidative decomposition-based fluorescence probe for highly selective detection of Cu2+ in tap water as well as cell imaging | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cu2+ detection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cell imaging | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hydrazide derivatives | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Aceanthrenequinone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Turn on fluorescence probe | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Okamoto, Yusuke
× Okamoto, Yusuke× Kishikawa, Naoya× Hagimori, Masayori× El-Maghrabey, Mahmoud× Kawakami, Shigeru× Kuroda, Naotaka |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Copper (II) is one of the most important metal ions for the human body that act as a catalytic cofactor for many metalloenzymes and proteins, and its homeostasis disruption could lead to many neurological diseases. The reported probes for Cu (II) determination are mostly based on fluorescence quenching mechanism, which pro-vides low precision and reliability. In the present work, a turn-on fluorescence probe, (Z)-1-[2-oxo-2-[2-[1-oxoaceanthrylen-2 (1H)-ylidene]hydrazinyl]ethyl]-pyridinium (OAHP), for highly selective detection of Cu2+ was developed. Hydrazide moiety of OAHP quenches probe fluorescence; however, upon its reaction with Cu, oxidative cleavage of the hydrazide moiety and intramolecular cyclization occurs, forming oxadiazole derivative with strong fluorescent properties. In this context, OAHP displayed significant fluorescence enhancement with increasing levels of Cu2+. OAHP could detect Cu2+ selectively with a detection limit of 18 nM (1.1 ppb). This is the first report for a probe that uses the ability of Cu2+ to induce oxidative decomposition of hydrazide with intramolecular cyclization, and it showed exceptional selective performance and exquisite sensitivity. Next, the method was applied successfully for monitoring Cu2+ in tap water samples with good accuracy(found% of 95.8–101.5%) and precisions (RSD<10%). Finally, OAHP was successfully applied for imaging Cu2+ in living cells, and this result indicates the potential of OAHP for selective detection of Cu2+ in complicated matrices. | |||||
書誌情報 |
Analytica Chimica Acta 巻 1217, p. 340024, 発行日 2022-05-30 |
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出版者 | ||||||
出版者 | Elsevier B.V. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00032670 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.aca.2022.340024 | |||||
権利 | ||||||
権利情報 | © 2022 Elsevier B.V.This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Analytica Chimica Acta, 1217, art. no. 340024; 2022 |