Item type |
学術雑誌論文 / Journal Article(1) |
公開日 |
2018-03-06 |
タイトル |
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タイトル |
Oral epithelial cell sheets engraftment for esophageal strictures after endoscopic submucosal dissection of squamous cell carcinoma and airplane transportation |
言語 |
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言語 |
eng |
資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
著者 |
Yamaguchi, Naoyuki
Isomoto, Hajime
Kobayashi, Shinichiro
Kanai, Nobuo
Kanetaka, Kengo
Sakai, Yusuke
Kasai, Yoshiyuki
Takagi, Ryo
Ohki, Takeshi
Fukuda, Hiroko
Kanda, Tsutomu
Nagai, Kazuhiro
Asahina, Izumi
Nakao, Kazuhiko
Yamato, Masayuki
Okano, Teruo
Eguchi, Susumu
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抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Endoscopic submucosal dissection (ESD) permits en bloc removal of superficial oesophageal squamous cell carcinoma (ESCC). However, post-procedure stricture is common after ESD for widespread tumours, and multiple endoscopic balloon dilation (EBD) procedures are required. We aimed to evaluate the safety and effectiveness of endoscopic transplantation of tissue-engineered autologous oral mucosal epithelial cell sheets that had been transported by air over a distance of 1200?km in controlling postprocedural oesophageal stricture. Ten patients who underwent complete circular or semicircular ESD for ESCC were transplanted with cell sheets. The safety of the entire process including cell sheet preparation, transport, ESD and cell sheet transplantation was assessed. The incidence of oesophageal stricture, number of EBD sessions, and time until epithelialization were investigated. Each ESD was successfully performed, with subsequent cell sheet engrafting carried out safely. Following cell sheet transplantation, the luminal stenosis rate was 40%, while the median number of EBD sessions was 0. The median post-ESD ulcer healing period was rather short at 36 days. There were no significant complications at any stage of the process. Cell sheet transplantation and preparation at distant sites and transportation by air could be a safe and promising regenerative medicine technology. |
書誌情報 |
Scientific Reports
巻 7,
p. 17460,
発行日 2017-12-12
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出版者 |
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出版者 |
Springer Nature |
EISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
20452322 |
DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1038/s41598-017-17663-w |
権利 |
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権利情報 |
c The Author(s) 2017 |
権利 |
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権利情報 |
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
引用 |
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内容記述タイプ |
Other |
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内容記述 |
Scientific Reports, 7, 17460; 2017 |